Search Results
Overview
| Uniprot ID | Q92572 |
|---|---|
| Protein Name | AP-3 complex subunit sigma-1 |
| Gene Name | AP3S1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 166 | ARAVSAVKNMNLPEI |
Function
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals
Protein Sequence
10
MIKAILIFNN
20
HGKPRLSKFY
30
QPYSEDTQQQ
40
IIRETFHLVS
50
KRDENVCNFL
60
EGGLLIGGSD
70
NKLIYRHYAT
80
LYFVFCVDSS
90
ESELGILDLI
100
QVFVETLDKC
110
FENVCELDLI
120
FHVDKVHNIL
130
AEMVMGGMVL
140
ETNMNEIVTQ
150
IDAQNKLEKS
160
EAGLAGAPAR
170
AVSAVKNMNL
180
PEIPRNINIG
190
DISIKVPNLP
SFK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030123 | AP-3 adaptor complex |
| Cellular Component | GO:0030119 | AP-type membrane coat adaptor complex |
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0030659 | cytoplasmic vesicle membrane |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0030133 | transport vesicle |
| Biological Process | GO:0008089 | anterograde axonal transport |
| Biological Process | GO:0048490 | anterograde synaptic vesicle transport |
| Biological Process | GO:0035654 | clathrin-coated vesicle cargo loading, AP-3-mediated |
| Biological Process | GO:0006896 | Golgi to vacuole transport |
| Biological Process | GO:0008286 | insulin receptor signaling pathway |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:1903232 | melanosome assembly |
| Biological Process | GO:0060155 | platelet dense granule organization |
| Biological Process | GO:0016183 | synaptic vesicle coating |
| Biological Process | GO:0036465 | synaptic vesicle recycling |
| Biological Process | GO:0016192 | vesicle-mediated transport |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.