Search Results
Overview
| Uniprot ID | Q92575 |
|---|---|
| Protein Name | UBX domain-containing protein 4 |
| Gene Name | UBXN4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 233 | IERRKTGKEMLDYKR |
| 269 | RAARERIKQQIALDR |
| 287 | AARFAKTKEEVEAAK |
Function
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669)
Protein Sequence
10
MLWFQGAIPA
20
AIATAKRSGA
30
VFVVFVAGDD
40
EQSTQMAASW
50
EDDKVTEASS
60
NSFVAIKIDT
70
KSEACLQFSQ
80
IYPVVCVPSS
90
FFIGDSGIPL
100
EVIAGSVSAD
110
ELVTRIHKVR
120
QMHLLKSETS
130
VANGSQSESS
140
VSTPSASFEP
150
NNTCENSQSR
160
NAELCEIPPT
170
SDTKSDTATG
180
GESAGHATSS
190
QEPSGCSDQR
200
PAEDLNIRVE
210
RLTKKLEERR
220
EEKRKEEEQR
230
EIKKEIERRK
240
TGKEMLDYKR
250
KQEEELTKRM
260
LEERNREKAE
270
DRAARERIKQ
280
QIALDRAERA
290
ARFAKTKEEV
300
EAAKAAALLA
310
KQAEMEVKRE
320
SYARERSTVA
330
RIQFRLPDGS
340
SFTNQFPSDA
350
PLEEARQFAA
360
QTVGNTYGNF
370
SLATMFPRRE
380
FTKEDYKKKL
390
LDLELAPSAS
400
VVLLPAGRPT
410
ASIVHSSSGD
420
IWTLLGTVLY
430
PFLAIWRLIS
440
NFLFSNPPPT
450
QTSVRVTSSE
460
PPNPASSSKS
470
EKREPVRKRV
480
LEKRGDDFKK
490
EGKIYRLRTQ
500
DDGEDENNTW
NGNSTQQM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Biological Process | GO:0036503 | ERAD pathway |
| Biological Process | GO:0006986 | response to unfolded protein |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.