Overview
| Uniprot ID | Q92597 |
|---|
| Protein Name | Protein NDRG1 |
|---|
| Gene Name | NDRG1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 280 |
NSKLDPTKTTLLKMA |
Function
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy
Protein Sequence
10
MSREMQDVDL
20
AEVKPLVEKG
30
ETITGLLQEF
40
DVQEQDIETL
50
HGSVHVTLCG
60
TPKGNRPVIL
70
TYHDIGMNHK
80
TCYNPLFNYE
90
DMQEITQHFA
100
VCHVDAPGQQ
110
DGAASFPAGY
120
MYPSMDQLAE
130
MLPGVLQQFG
140
LKSIIGMGTG
150
AGAYILTRFA
160
LNNPEMVEGL
170
VLINVNPCAE
180
GWMDWAASKI
190
SGWTQALPDM
200
VVSHLFGKEE
210
MQSNVEVVHT
220
YRQHIVNDMN
230
PGNLHLFINA
240
YNSRRDLEIE
250
RPMPGTHTVT
260
LQCPALLVVG
270
DSSPAVDAVV
280
ECNSKLDPTK
290
TTLLKMADCG
300
GLPQISQPAK
310
LAEAFKYFVQ
320
GMGYMPSASM
330
TRLMRSRTAS
340
GSSVTSLDGT
350
RSRSHTSEGT
360
RSRSHTSEGT
370
RSRSHTSEGA
380
HLDITPNSGA
390
AGNSAGPKSM
EVSC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005912 |
adherens junction |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0043015 |
gamma-tubulin binding |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0016151 |
nickel cation binding |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Biological Process |
GO:0071456 |
cellular response to hypoxia |
| Biological Process |
GO:0030330 |
DNA damage response, signal transduction by p53 class mediator |
| Biological Process |
GO:0008285 |
negative regulation of cell population proliferation |
| Biological Process |
GO:0032287 |
peripheral nervous system myelin maintenance |
| Biological Process |
GO:0010038 |
response to metal ion |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.