Search Results

Overview

Uniprot IDQ92598
Protein NameHeat shock protein 105 kDa
Gene NameHSPH1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
126 AMLLTKLKETAENSL
249 EHFCAEFKTKYKLDA
388 AILSPAFKVREFSVT
471 VQNVSAQKDGEKSRV
772 VMNAQAKKSLDQDPV
806 VVTQPKPKIESPKLE
84 DPFIQKEKENLSYDL

Function

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity)

Protein Sequence

10 MSVVGLDVGS 20 QSCYIAVARA 30 GGIETIANEF 40 SDRCTPSVIS 50 FGSKNRTIGV 60 AAKNQQITHA 70 NNTVSNFKRF 80 HGRAFNDPFI 90 QKEKENLSYD 100 LVPLKNGGVG 110 IKVMYMGEEH 120 LFSVEQITAM 130 LLTKLKETAE 140 NSLKKPVTDC 150 VISVPSFFTD 160 AERRSVLDAA 170 QIVGLNCLRL 180 MNDMTAVALN 190 YGIYKQDLPS 200 LDEKPRIVVF 210 VDMGHSAFQV 220 SACAFNKGKL 230 KVLGTAFDPF 240 LGGKNFDEKL 250 VEHFCAEFKT 260 KYKLDAKSKI 270 RALLRLYQEC 280 EKLKKLMSSN 290 STDLPLNIEC 300 FMNDKDVSGK 310 MNRSQFEELC 320 AELLQKIEVP 330 LYSLLEQTHL 340 KVEDVSAVEI 350 VGGATRIPAV 360 KERIAKFFGK 370 DISTTLNADE 380 AVARGCALQC 390 AILSPAFKVR 400 EFSVTDAVPF 410 PISLIWNHDS 420 EDTEGVHEVF 430 SRNHAAPFSK 440 VLTFLRRGPF 450 ELEAFYSDPQ 460 GVPYPEAKIG 470 RFVVQNVSAQ 480 KDGEKSRVKV 490 KVRVNTHGIF 500 TISTASMVEK 510 VPTEENEMSS 520 EADMECLNQR 530 PPENPDTDKN 540 VQQDNSEAGT 550 QPQVQTDAQQ 560 TSQSPPSPEL 570 TSEENKIPDA 580 DKANEKKVDQ 590 PPEAKKPKIK 600 VVNVELPIEA 610 NLVWQLGKDL 620 LNMYIETEGK 630 MIMQDKLEKE 640 RNDAKNAVEE 650 YVYEFRDKLC 660 GPYEKFICEQ 670 DHQNFLRLLT 680 ETEDWLYEEG 690 EDQAKQAYVD 700 KLEELMKIGT 710 PVKVRFQEAE 720 ERPKMFEELG 730 QRLQHYAKIA 740 ADFRNKDEKY 750 NHIDESEMKK 760 VEKSVNEVME 770 WMNNVMNAQA 780 KKSLDQDPVV 790 RAQEIKTKIK 800 ELNNTCEPVV 810 TQPKPKIESP 820 KLERTPNGPN 830 IDKKEEDLED 840 KNNFGAEPPH 850 QNGECYPNEK NSVNMDLD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0071682 endocytic vesicle lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0000774 adenyl-nucleotide exchange factor activity
Molecular Function GO:0043014 alpha-tubulin binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Biological Process GO:0045345 positive regulation of MHC class I biosynthetic process
Biological Process GO:0051135 positive regulation of NK T cell activation
Biological Process GO:0006457 protein folding
Biological Process GO:0006986 response to unfolded protein

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.