Search Results
Overview
| Uniprot ID | Q92599 |
|---|---|
| Protein Name | Septin-8 |
| Gene Name | SEPTIN8 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 193 | AKADTISKSELHKFK |
| 369 | KERELHEKFEHLKRV |
| 402 | TNAFNRRKAAVEALQ |
Function
Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity)
Protein Sequence
10
MAATDLERFS
20
NAEPEPRSLS
30
LGGHVGFDSL
40
PDQLVSKSVT
50
QGFSFNILCV
60
GETGIGKSTL
70
MNTLFNTTFE
80
TEEASHHEAC
90
VRLRPQTYDL
100
QESNVQLKLT
110
IVDAVGFGDQ
120
INKDESYRPI
130
VDYIDAQFEN
140
YLQEELKIRR
150
SLFDYHDTRI
160
HVCLYFITPT
170
GHSLKSLDLV
180
TMKKLDSKVN
190
IIPIIAKADT
200
ISKSELHKFK
210
IKIMGELVSN
220
GVQIYQFPTD
230
DEAVAEINAV
240
MNAHLPFAVV
250
GSTEEVKVGN
260
KLVRARQYPW
270
GVVQVENENH
280
CDFVKLREML
290
IRVNMEDLRE
300
QTHSRHYELY
310
RRCKLEEMGF
320
QDSDGDSQPF
330
SLQETYEAKR
340
KEFLSELQRK
350
EEEMRQMFVN
360
KVKETELELK
370
EKERELHEKF
380
EHLKRVHQEE
390
KRKVEEKRRE
400
LEEETNAFNR
410
RKAAVEALQS
420
QALHATSQQP
430
LRKDKDKKNR
440
SDIGAHQPGM
450
SLSSSKVMMT
460
KASVEPLNCS
470
SWWPAIQCCS
480
CLVRDATWRE
GFL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0032153 | cell division site |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0031105 | septin complex |
| Cellular Component | GO:0005940 | septin ring |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Biological Process | GO:0061640 | cytoskeleton-dependent cytokinesis |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0033157 | regulation of intracellular protein transport |
| Biological Process | GO:0031647 | regulation of protein stability |
| Biological Process | GO:0035542 | regulation of SNARE complex assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.