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Overview

Uniprot IDQ92608
Protein NameDedicator of cytokinesis protein 2
Gene NameDOCK2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
578 YRHHVENKGATLSRS

Function

Guanine nucleotide exchange factor (GEF) that activates monomeric GTPases by catalysing the release of bound GDP in exchange for free GTP (PubMed:32651375). Activates RAC1 and RAC2, but not CDC42 (PubMed:21613211, PubMed:32651375). Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines (PubMed:21613211). May also participate in IL2 transcriptional activation via the activation of RAC2 (PubMed:21613211)

Protein Sequence

10 MAPWRKADKE 20 RHGVAIYNFQ 30 GSGAPQLSLQ 40 IGDVVRIQET 50 CGDWYRGYLI 60 KHKMLQGIFP 70 KSFIHIKEVT 80 VEKRRNTENI 90 IPAEIPLAQE 100 VTTTLWEWGS 110 IWKQLYVASK 120 KERFLQVQSM 130 MYDLMEWRSQ 140 LLSGTLPKDE 150 LKELKQKVTS 160 KIDYGNKILE 170 LDLIVRDEDG 180 NILDPDNTSV 190 ISLFHAHEEA 200 TDKITERIKE 210 EMSKDQPDYA 220 MYSRISSSPT 230 HSLYVFVRNF 240 VCRIGEDAEL 250 FMSLYDPNKQ 260 TVISENYLVR 270 WGSRGFPKEI 280 EMLNNLKVVF 290 TDLGNKDLNR 300 DKIYLICQIV 310 RVGKMDLKDT 320 GAKKCTQGLR 330 RPFGVAVMDI 340 TDIIKGKAES 350 DEEKQHFIPF 360 HPVTAENDFL 370 HSLLGKVIAS 380 KGDSGGQGLW 390 VTMKMLVGDI 400 IQIRKDYPHL 410 VDRTTVVARK 420 LGFPEIIMPG 430 DVRNDIYITL 440 LQGDFDKYNK 450 TTQRNVEVIM 460 CVCAEDGKTL 470 PNAICVGAGD 480 KPMNEYRSVV 490 YYQVKQPRWM 500 ETVKVAVPIE 510 DMQRIHLRFM 520 FRHRSSLESK 530 DKGEKNFAMS 540 YVKLMKEDGT 550 TLHDGFHDLV 560 VLKGDSKKME 570 DASAYLTLPS 580 YRHHVENKGA 590 TLSRSSSSVG 600 GLSVSSRDVF 610 SISTLVCSTK 620 LTQNVGLLGL 630 LKWRMKPQLL 640 QENLEKLKIV 650 DGEEVVKFLQ 660 DTLDALFNIM 670 MEHSQSDEYD 680 ILVFDALIYI 690 IGLIADRKFQ 700 HFNTVLEAYI 710 QQHFSATLAY 720 KKLMTVLKTY 730 LDTSSRGEQC 740 EPILRTLKAL 750 EYVFKFIVRS 760 RTLFSQLYEG 770 KEQMEFEESM 780 RRLFESINNL 790 MKSQYKTTIL 800 LQVAALKYIP 810 SVLHDVEMVF 820 DAKLLSQLLY 830 EFYTCIPPVK 840 LQKQKVQSMN 850 EIVQSNLFKK 860 QECRDILLPV 870 ITKELKELLE 880 QKDDMQHQVL 890 ERKYCVELLN 900 SILEVLSYQD 910 AAFTYHHIQE 920 IMVQLLRTVN 930 RTVITMGRDH 940 ILISHFVACM 950 TAILNQMGDQ 960 HYSFYIETFQ 970 TSSELVDFLM 980 ETFIMFKDLI 990 GKNVYPGDWM 1000 AMSMVQNRVF 1010 LRAINKFAET 1020 MNQKFLEHTN 1030 FEFQLWNNYF 1040 HLAVAFITQD 1050 SLQLEQFSHA 1060 KYNKILNKYG 1070 DMRRLIGFSI 1080 RDMWYKLGQN 1090 KICFIPGMVG 1100 PILEMTLIPE 1110 AELRKATIPI 1120 FFDMMLCEYQ 1130 RSGDFKKFEN 1140 EIILKLDHEV 1150 EGGRGDEQYM 1160 QLLESILMEC 1170 AAEHPTIAKS 1180 VENFVNLVKG 1190 LLEKLLDYRG 1200 VMTDESKDNR 1210 MSCTVNLLNF 1220 YKDNNREEMY 1230 IRYLYKLRDL 1240 HLDCDNYTEA 1250 AYTLLLHTWL 1260 LKWSDEQCAS 1270 QVMQTGQQHP 1280 QTHRQLKETL 1290 YETIIGYFDK 1300 GKMWEEAISL 1310 CKELAEQYEM 1320 EIFDYELLSQ 1330 NLIQQAKFYE 1340 SIMKILRPKP 1350 DYFAVGYYGQ 1360 GFPSFLRNKV 1370 FIYRGKEYER 1380 REDFQMQLMT 1390 QFPNAEKMNT 1400 TSAPGDDVKN 1410 APGQYIQCFT 1420 VQPVLDEHPR 1430 FKNKPVPDQI 1440 INFYKSNYVQ 1450 RFHYSRPVRR 1460 GTVDPENEFA 1470 SMWIERTSFV 1480 TAYKLPGILR 1490 WFEVVHMSQT 1500 TISPLENAIE 1510 TMSTANEKIL 1520 MMINQYQSDE 1530 TLPINPLSML 1540 LNGIVDPAVM 1550 GGFAKYEKAF 1560 FTEEYVRDHP 1570 EDQDKLTHLK 1580 DLIAWQIPFL 1590 GAGIKIHEKR 1600 VSDNLRPFHD 1610 RMEECFKNLK 1620 MKVEKEYGVR 1630 EMPDFDDRRV 1640 GRPRSMLRSY 1650 RQMSIISLAS 1660 MNSDCSTPSK 1670 PTSESFDLEL 1680 ASPKTPRVEQ 1690 EEPISPGSTL 1700 PEVKLRRSKK 1710 RTKRSSVVFA 1720 DEKAAAESDL 1730 KRLSRKHEFM 1740 SDTNLSEHAA 1750 IPLKASVLSQ 1760 MSFASQSMPT 1770 IPALALSVAG 1780 IPGLDEANTS 1790 PRLSQTFLQL 1800 SDGDKKTLTR 1810 KKVNQFFKTM 1820 LASKSAEEGK 1830 QIPDSLSTDL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0035580 specific granule lumen
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0031267 small GTPase binding
Molecular Function GO:0042608 T cell receptor binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0016477 cell migration
Biological Process GO:0044351 macropinocytosis
Biological Process GO:0002277 myeloid dendritic cell activation involved in immune response
Biological Process GO:0007520 myoblast fusion
Biological Process GO:0050766 positive regulation of phagocytosis
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007264 small GTPase-mediated signal transduction

Reference

[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.