Search Results

Overview

Uniprot IDQ92610
Protein NameZinc finger protein 592
Gene NameZNF592
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
316 KDLSGPTKESSKGSP
341 SPLEATRKSIKPSDS
374 SSPPAIPKVRIKTIK
381 KVRIKTIKTSSGEIK
388 KTSSGEIKRTVTRIL
471 SSGPRVPKGAAPGSQ
546 PLVHQVKKAAPLIVE
642 HARDHKSKGLVMQCS

Function

May be involved in transcriptional regulation

Protein Sequence

10 MGDMKTPDFD 20 DLLAAFDIPD 30 PTSLDAKEAI 40 QTPSEENESP 50 LKPPGICMDE 60 SVSLSHSGSA 70 PDVPAVSVIV 80 KNTSRQESFE 90 AEKDHITPSL 100 LHNGFRGSDL 110 PPDPHNCGKF 120 DSTFMNGDSA 130 RSFPGKLEPP 140 KSEPLPTFNQ 150 FSPISSPEPE 160 DPIKDNGFGI 170 KPKHSDSYFP 180 PPLGCGAVGG 190 PVLEALAKFP 200 VPELHMFDHF 210 CKKEPKPEPL 220 PLGSQQEHEQ 230 SGQNTVEPHK 240 DPDATRFFGE 250 ALEFNSHPSN 260 SIGESKGLAR 270 ELGTCSSVPP 280 RQRLKPAHSK 290 LSSCVAALVA 300 LQAKRVASVT 310 KEDQPGHTKD 320 LSGPTKESSK 330 GSPKMPKSPK 340 SPRSPLEATR 350 KSIKPSDSPR 360 SICSDSSSKG 370 SPSVAASSPP 380 AIPKVRIKTI 390 KTSSGEIKRT 400 VTRILPDPDD 410 PSKSPVGSPL 420 GSAIAEAPSE 430 MPGDEVPVEE 440 HFPEAGTNSG 450 SPQGARKGDE 460 SMTKASDSSS 470 PSCSSGPRVP 480 KGAAPGSQTG 490 KKQQSTALQA 500 STLAPANLLP 510 KAVHLANLNL 520 VPHSVAASVT 530 AKSSVQRRSQ 540 PQLTQMSVPL 550 VHQVKKAAPL 560 IVEVFNKVLH 570 SSNPVPLYAP 580 NLSPPADSRI 590 HVPASGYCCL 600 ECGDAFALEK 610 SLSQHYGRRS 620 VHIEVLCTLC 630 SKTLLFFNKC 640 SLLRHARDHK 650 SKGLVMQCSQ 660 LLVKPISADQ 670 MFVSAPVNST 680 APAAPAPSSS 690 PKHGLTSGSA 700 SPPPPALPLY 710 PDPVRLIRYS 720 IKCLECHKQM 730 RDYMVLAAHF 740 QRTTEETEGL 750 TCQVCQMLLP 760 NQCSFCAHQR 770 IHAHKSPYCC 780 PECGVLCRSA 790 YFQTHVKENC 800 LHYARKVGYR 810 CIHCGVVHLT 820 LALLKSHIQE 830 RHCQVFHKCA 840 FCPMAFKTAS 850 STADHSATQH 860 PTQPHRPSQL 870 IYKCSCEMVF 880 NKKRHIQQHF 890 YQNVSKTQVG 900 VFKCPECPLL 910 FVQKPELMQH 920 VKSTHGVPRN 930 VDELSSLQSS 940 ADTSSSRPGS 950 RVPTEPPATS 960 VAARSSSLPS 970 GRWGRPEAHR 980 RVEARPRLRN 990 TGWTCQECQE 1000 WVPDRESYVS 1010 HMKKSHGRTL 1020 KRYPCRQCEQ 1030 SFHTPNSLRK 1040 HIRNNHDTVK 1050 KFYTCGYCTE 1060 DSPSFPRPSL 1070 LESHISLMHG 1080 IRNPDLSQTS 1090 KVKPPGGHSP 1100 QVNHLKRPVS 1110 GVGDAPGTSN 1120 GATVSSTKRH 1130 KSLFQCAKCS 1140 FATDSGLEFQ 1150 SHIPQHQVDS 1160 STAQCLLCGL 1170 CYTSASSLSR 1180 HLFIVHKVRD 1190 QEEEEEEEAA 1200 AAEMAVEVAE 1210 PEEGSGEEVP 1220 METRENGLEE 1230 CAGEPLSADP 1240 EARRLLGPAP 1250 EDDGGHNDHS 1260 QPQASQDQDS HTLSPQV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.