Search Results

Overview

Uniprot IDQ92613
Protein NameProtein Jade-3
Gene NameJADE3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
738 QCYVKPTKNMSPKEQ
812 RDCHGKSKTHPLSHS

Function

Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity

Protein Sequence

10 MKRHRPVSSS 20 DSSDESPSTS 30 FTSGSMYRIK 40 SKIPNEHKKP 50 AEVFRKDLIS 60 AMKLPDSHHI 70 NPDSYYLFAD 80 TWKEEWEKGV 90 QVPASPDTVP 100 QPSLRIIAEK 110 VKDVLFIRPR 120 KYIHCSSPDT 130 TEPGYINIME 140 LAASVCRYDL 150 DDMDIFWLQE 160 LNEDLAEMGC 170 GPVDENLMEK 180 TVEVLERHCH 190 ENMNHAIETE 200 EGLGIEYDED 210 VICDVCRSPD 220 SEEGNDMVFC 230 DKCNVCVHQA 240 CYGILKVPEG 250 SWLCRSCVLG 260 IYPQCVLCPK 270 KGGALKTTKT 280 GTKWAHVSCA 290 LWIPEVSIAC 300 PERMEPITKI 310 SHIPPSRWAL 320 VCNLCKLKTG 330 ACIQCSIKSC 340 ITAFHVTCAF 350 EHGLEMKTIL 360 DEGDEVKFKS 370 YCLKHSQNRQ 380 KLGEAEYPHH 390 RAKEQSQAKS 400 EKTSLRAQKL 410 RELEEEFYSL 420 VRVEDVAAEL 430 GMPTLAVDFI 440 YNYWKLKRKS 450 NFNKPLFPPK 460 EDEENGLVQP 470 KEESIHTRMR 480 MFMHLRQDLE 490 RVRNLCYMIS 500 RREKLKLSHN 510 KIQEQIFGLQ 520 VQLLNQEIDA 530 GLPLTNALEN 540 SLFYPPPRIT 550 LKLKMPKSTP 560 EDHRNSSTET 570 DQQPHSPDSS 580 SSVHSIRNMQ 590 VPQESLEMRT 600 KSYPRYPLES 610 KNNRLLASLS 620 HSRSEAKESS 630 PAWRTPSSEC 640 YHGQSLGKPL 650 VLQAALHGQS 660 SIGNGKSQPN 670 SKFAKSNGLE 680 GSWSGNVTQK 690 DSSSEMFCDQ 700 EPVFSPHLVS 710 QGSFRKSTVE 720 HFSRSFKETT 730 NRWVKNTEDL 740 QCYVKPTKNM 750 SPKEQFWGRQ 760 VLRRSAGRAP 770 YQENDGYCPD 780 LELSDSEAES 790 DGNKEKVRVR 800 KDSSDRENPP 810 HDSRRDCHGK 820 SKTHPLSHSS MQR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000123 histone acetyltransferase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0140566 histone reader activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:2000278 regulation of DNA biosynthetic process
Biological Process GO:0006275 regulation of DNA replication
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.