Search Results

Overview

Uniprot ID	Q92614
Protein Name	Unconventional myosin-XVIIIa
Gene Name	MYO18A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1037	DALIDTIKKSKLHFV
123	SVLQRAAKFGSLAKQ
1995	SKNKGPSKAASDDGS

Function

May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939)

Protein Sequence

10 MFNLMKKDKD 20 KDGGRKEKKE 30 KKEKKERMSA 40 AELRSLEEMS 50 LRRGFFNLNR 60 SSKRESKTRL 70 EISNPIPIKV 80 ASGSDLHLTD 90 IDSDSNRGSV 100 ILDSGHLSTA 110 SSSDDLKGEE 120 GSFRGSVLQR 130 AAKFGSLAKQ 140 NSQMIVKRFS 150 FSQRSRDESA 160 SETSTPSEHS 170 AAPSPQVEVR 180 TLEGQLVQHP 190 GPGIPRPGHR 200 SRAPELVTKK 210 FPVDLRLPPV 220 VPLPPPTLRE 230 LELQRRPTGD 240 FGFSLRRTTM 250 LDRGPEGQAC 260 RRVVHFAEPG 270 AGTKDLALGL 280 VPGDRLVEIN 290 GHNVESKSRD 300 EIVEMIRQSG 310 DSVRLKVQPI 320 PELSELSRSW 330 LRSGEGPRRE 340 PSDAKTEEQI 350 AAEEAWNETE 360 KVWLVHRDGF 370 SLASQLKSEE 380 LNLPEGKVRV 390 KLDHDGAILD 400 VDEDDVEKAN 410 APSCDRLEDL 420 ASLVYLNESS 430 VLHTLRQRYG 440 ASLLHTYAGP 450 SLLVLGPRGA 460 PAVYSEKVMH 470 MFKGCRREDM 480 APHIYAVAQT 490 AYRAMLMSRQ 500 DQSIILLGSS 510 GSGKTTSCQH 520 LVQYLATIAG 530 ISGNKVFSVE 540 KWQALYTLLE 550 AFGNSPTIIN 560 GNATRFSQIL 570 SLDFDQAGQV 580 ASASIQTMLL 590 EKLRVARRPA 600 SEATFNVFYY 610 LLACGDGTLR 620 TELHLNHLAE 630 NNVFGIVPLA 640 KPEEKQKAAQ 650 QFSKLQAAMK 660 VLGISPDEQK 670 ACWFILAAIY 680 HLGAAGATKE 690 AAEAGRKQFA 700 RHEWAQKAAY 710 LLGCSLEELS 720 SAIFKHQHKG 730 GTLQRSTSFR 740 QGPEESGLGD 750 GTGPKLSALE 760 CLEGMAAGLY 770 SELFTLLVSL 780 VNRALKSSQH 790 SLCSMMIVDT 800 PGFQNPEQGG 810 SARGASFEEL 820 CHNYTQDRLQ 830 RLFHERTFVQ 840 ELERYKEENI 850 ELAFDDLEPP 860 TDDSVAAVDQ 870 ASHQSLVRSL 880 ARTDEARGLL 890 WLLEEEALVP 900 GASEDTLLER 910 LFSYYGPQEG 920 DKKGQSPLLH 930 SSKPHHFLLG 940 HSHGTNWVEY 950 NVTGWLNYTK 960 QNPATQNAPR 970 LLQDSQKKII 980 SNLFLGRAGS 990 ATVLSGSIAG 1000 LEGGSQLALR 1010 RATSMRKTFT 1020 TGMAAVKKKS 1030 LCIQMKLQVD 1040 ALIDTIKKSK 1050 LHFVHCFLPV 1060 AEGWAGEPRS 1070 ASSRRVSSSS 1080 ELDLPSGDHC 1090 EAGLLQLDVP 1100 LLRTQLRGSR 1110 LLDAMRMYRQ 1120 GYPDHMVFSE 1130 FRRRFDVLAP 1140 HLTKKHGRNY 1150 IVVDERRAVE 1160 ELLECLDLEK 1170 SSCCMGLSRV 1180 FFRAGTLARL 1190 EEQRDEQTSR 1200 NLTLFQAACR 1210 GYLARQHFKK 1220 RKIQDLAIRC 1230 VQKNIKKNKG 1240 VKDWPWWKLF 1250 TTVRPLIEVQ 1260 LSEEQIRNKD 1270 EEIQQLRSKL 1280 EKAEKERNEL 1290 RLNSDRLESR 1300 ISELTSELTD 1310 ERNTGESASQ 1320 LLDAETAERL 1330 RAEKEMKELQ 1340 TQYDALKKQM 1350 EVMEMEVMEA 1360 RLIRAAEING 1370 EVDDDDAGGE 1380 WRLKYERAVR 1390 EVDFTKKRLQ 1400 QEFEDKLEVE 1410 QQNKRQLERR 1420 LGDLQADSEE 1430 SQRALQQLKK 1440 KCQRLTAELQ 1450 DTKLHLEGQQ 1460 VRNHELEKKQ 1470 RRFDSELSQA 1480 HEEAQREKLQ 1490 REKLQREKDM 1500 LLAEAFSLKQ 1510 QLEEKDMDIA 1520 GFTQKVVSLE 1530 AELQDISSQE 1540 SKDEASLAKV 1550 KKQLRDLEAK 1560 VKDQEEELDE 1570 QAGTIQMLEQ 1580 AKLRLEMEME 1590 RMRQTHSKEM 1600 ESRDEEVEEA 1610 RQSCQKKLKQ 1620 MEVQLEEEYE 1630 DKQKVLREKR 1640 ELEGKLATLS 1650 DQVNRRDFES 1660 EKRLRKDLKR 1670 TKALLADAQL 1680 MLDHLKNSAP 1690 SKREIAQLKN 1700 QLEESEFTCA 1710 AAVKARKAME 1720 VEIEDLHLQI 1730 DDIAKAKTAL 1740 EEQLSRLQRE 1750 KNEIQNRLEE 1760 DQEDMNELMK 1770 KHKAAVAQAS 1780 RDLAQINDLQ 1790 AQLEEANKEK 1800 QELQEKLQAL 1810 QSQVEFLEQS 1820 MVDKSLVSRQ 1830 EAKIRELETR 1840 LEFERTQVKR 1850 LESLASRLKE 1860 NMEKLTEERD 1870 QRIAAENREK 1880 EQNKRLQRQL 1890 RDTKEEMGEL 1900 ARKEAEASRK 1910 KHELEMDLES 1920 LEAANQSLQA 1930 DLKLAFKRIG 1940 DLQAAIEDEM 1950 ESDENEDLIN 1960 SLQDMVTKYQ 1970 KRKNKLEGDS 1980 DVDSELEDRV 1990 DGVKSWLSKN 2000 KGPSKAASDD 2010 GSLKSSSPTS 2020 YWKSLAPDRS 2030 DDEHDPLDNT 2040 SRPRYSHSYL 2050 SDSDTEAKLT ETNA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005815	microtubule organizing center
Cellular Component	GO:0032982	myosin filament
Cellular Component	GO:0016460	myosin II complex
Cellular Component	GO:0005802	trans-Golgi network
Molecular Function	GO:0051015	actin filament binding
Molecular Function	GO:0043531	ADP binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0031032	actomyosin structure organization
Biological Process	GO:0090164	asymmetric Golgi ribbon formation
Biological Process	GO:0016477	cell migration
Biological Process	GO:0006259	DNA metabolic process
Biological Process	GO:0007030	Golgi organization
Biological Process	GO:0090161	Golgi ribbon formation
Biological Process	GO:0048194	Golgi vesicle budding
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:1903028	positive regulation of opsonization
Biological Process	GO:0050714	positive regulation of protein secretion
Biological Process	GO:0043030	regulation of macrophage activation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.