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Overview

Uniprot IDQ92618
Protein NameZinc finger protein 516
Gene NameZNF516
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1005 PPREPPSKAAQELRT
158 VLLRSSKKGAEGSAC
180 AVQCSFCKSQFERKK
286 HICGRRFKEPWFLKN
463 YVLVSQEKRKREQDA
513 AATTGQGKSSECFEC
522 SECFECGKIFRTYHQ
723 KEHSGGGKRALAPDL
78 ASQKGNLKIHIRSHR
975 HSAPDSLKAKFSAQP

Function

Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis (By similarity). May also play a role in the cellular response to replication stress (PubMed:23446422)

Protein Sequence

10 MDRNREAEME 20 LRRGPSPTRA 30 GRGHEVDGDK 40 ATCHTCCICG 50 KSFPFQSSLS 60 QHMRKHTGEK 70 PYKCPYCDHR 80 ASQKGNLKIH 90 IRSHRTGTLI 100 QGHEPEAGEA 110 PLGEMRASEG 120 LDACASPTKS 130 ASACNRLLNG 140 ASQADGARVL 150 NGASQADSGR 160 VLLRSSKKGA 170 EGSACAPGEA 180 KAAVQCSFCK 190 SQFERKKDLE 200 LHVHQAHKPF 210 KCRLCSYATL 220 REESLLSHIE 230 RDHITAQGPG 240 SGEACVENGK 250 PELSPGEFPC 260 EVCGQAFSQT 270 WFLKAHMKKH 280 RGSFDHGCHI 290 CGRRFKEPWF 300 LKNHMKAHGP 310 KTGSKNRPKS 320 ELDPIATINN 330 VVQEEVIVAG 340 LSLYEVCAKC 350 GNLFTNLDSL 360 NAHNAIHRRV 370 EASRTRAPAE 380 EGAEGPSDTK 390 QFFLQCLNLR 400 PSAAGDSCPG 410 TQAGRRVAEL 420 DPVNSYQAWQ 430 LATRGKVAEP 440 AEYLKYGAWD 450 EALAGDVAFD 460 KDRREYVLVS 470 QEKRKREQDA 480 PAAQGPPRKR 490 ASGPGDPAPA 500 GHLDPRSAAR 510 PNRRAAATTG 520 QGKSSECFEC 530 GKIFRTYHQM 540 VLHSRVHRRA 550 RRERDSDGDR 560 AARARCGSLS 570 EGDSASQPSS 580 PGSACAAADS 590 PGSGLADEAA 600 EDSGEEGAPE 610 PAPGGQPRRC 620 CFSEEVTSTE 630 LSSGDQSHKM 640 GDNASERDTG 650 ESKAGIAASV 660 SILENSSRET 670 SRRQEQHRFS 680 MDLKMPAFHP 690 KQEVPVPGDG 700 VEFPSSTGAE 710 GQTGHPAEKL 720 SDLHNKEHSG 730 GGKRALAPDL 740 MPLDLSARST 750 RDDPSNKETA 760 SSLQAALVVH 770 PCPYCSHKTY 780 YPEVLWMHKR 790 IWHRVSCNSV 800 APPWIQPNGY 810 KSIRSNLVFL 820 SRSGRTGPPP 830 ALGGKECQPL 840 LLARFTRTQV 850 PGGMPGSKSG 860 SSPLGVVTKA 870 ASMPKNKESH 880 SGGPCALWAP 890 GPDGYRQTKP 900 CHGQEPHGAA 910 TQGPLAKPRQ 920 EASSKPVPAP 930 GGGGFSRSAT 940 PTPTVIARAG 950 AQPSANSKPV 960 EKFGVPPAGA 970 GFAPTNKHSA 980 PDSLKAKFSA 990 QPQGPPPAKG 1000 EGGAPPLPPR 1010 EPPSKAAQEL 1020 RTLATCAAGS 1030 RGDAALQAQP 1040 GVAGAPPVLH 1050 SIKQEPVAEG 1060 HEKRLDILNI 1070 FKTYIPKDFA 1080 TLYQGWGVSG 1090 PGLEHRGTLR 1100 TQARPGEFVC 1110 IECGKSFHQP 1120 GHLRAHMRAH 1130 SVVFESDGPR 1140 GSEVHTTSAD 1150 APKQGRDHSN 1160 TGTVQTVPLR KGT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000987 cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0060612 adipose tissue development
Biological Process GO:0050873 brown fat cell differentiation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0009409 response to cold

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.