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Overview

Uniprot IDQ92619
Protein NameRho GTPase-activating protein 45
Gene NameARHGAP45
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
18 KTPSISKKNRAGSPS

Function

Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity

Protein Sequence

10 MFSRKKRELM 20 KTPSISKKNR 30 AGSPSPQPSG 40 ELPRKDGADA 50 VFPGPSLEPP 60 AGSSGVKATG 70 TLKRPTSLSR 80 HASAAGFPLS 90 GAASWTLGRS 100 HRSPLTAASP 110 GELPTEGAGP 120 DVVEDISHLL 130 ADVARFAEGL 140 EKLKECVLRD 150 DLLEARRPRA 160 HECLGEALRV 170 MHQIISKYPL 180 LNTVETLTAA 190 GTLIAKVKAF 200 HYESNNDLEK 210 QEFEKALETI 220 AVAFSSTVSE 230 FLMGEVDSST 240 LLAVPPGDSS 250 QSMESLYGPG 260 SEGTPPSLED 270 CDAGCLPAEE 280 VDVLLQRCEG 290 GVDAALLYAK 300 NMAKYMKDLI 310 SYLEKRTTLE 320 MEFAKGLQKI 330 AHNCRQSVMQ 340 EPHMPLLSIY 350 SLALEQDLEF 360 GHSMVQAVGT 370 LQTQTFMQPL 380 TLRRLEHEKR 390 RKEIKEAWHR 400 AQRKLQEAES 410 NLRKAKQGYV 420 QRCEDHDKAR 430 FLVAKAEEEQ 440 AGSAPGAGST 450 ATKTLDKRRR 460 LEEEAKNKAE 470 EAMATYRTCV 480 ADAKTQKQEL 490 EDTKVTALRQ 500 IQEVIRQSDQ 510 TIKSATISYY 520 QMMHMQTAPL 530 PVHFQMLCES 540 SKLYDPGQQY 550 ASHVRQLQRD 560 QEPDVHYDFE 570 PHVSANAWSP 580 VMRARKSSFN 590 VSDVARPEAA 600 GSPPEEGGCT 610 EGTPAKDHRA 620 GRGHQVHKSW 630 PLSISDSDSG 640 LDPGPGAGDF 650 KKFERTSSSG 660 TMSSTEELVD 670 PDGGAGASAF 680 EQADLNGMTP 690 ELPVAVPSGP 700 FRHEGLSKAA 710 RTHRLRKLRT 720 PAKCRECNSY 730 VYFQGAECEE 740 CCLACHKKCL 750 ETLAIQCGHK 760 KLQGRLQLFG 770 QDFSHAARSA 780 PDGVPFIVKK 790 CVCEIERRAL 800 RTKGIYRVNG 810 VKTRVEKLCQ 820 AFENGKELVE 830 LSQASPHDIS 840 NVLKLYLRQL 850 PEPLISFRLY 860 HELVGLAKDS 870 LKAEAEAKAA 880 SRGRQDGSES 890 EAVAVALAGR 900 LRELLRDLPP 910 ENRASLQYLL 920 RHLRRIVEVE 930 QDNKMTPGNL 940 GIVFGPTLLR 950 PRPTEATVSL 960 SSLVDYPHQA 970 RVIETLIVHY 980 GLVFEEEPEE 990 TPGGQDESSN 1000 QRAEVVVQVP 1010 YLEAGEAVVY 1020 PLQEAAADGC 1030 RESRVVSNDS 1040 DSDLEEASEL 1050 LSSSEASALG 1060 HLSFLEQQQS 1070 EASLEVASGS 1080 HSGSEEQLEA 1090 TAREDGDGDE 1100 DGPAQQLSGF 1110 NTNQSNNVLQ 1120 APLPPMRLRG 1130 GRMTLGSCRE RQPEFV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032587 ruffle membrane
Cellular Component GO:0034774 secretory granule lumen
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051058 negative regulation of small GTPase mediated signal transduction
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007165 signal transduction

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.