Search Results

Overview

Uniprot IDQ92620
Protein NamePre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
Gene NameDHX38
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1203 LGSVRSTKIYTPGRK
205 ESPRHRPKDAATPSR
260 RDRSVRGKYSDDTPL
28 QVGGLICKSKSAASE
30 GGLICKSKSAASEQH
40 ASEQHVFKAPAPRPS
466 ERKKAQHKHWELAGT
474 HWELAGTKLGDIMGV
504 VDYRTEQKFADHMKR
512 FADHMKRKSEASSEF
523 SSEFAKKKSILEQRQ
75 GEDKKKSKVSSYKDW

Function

Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131)

Protein Sequence

10 MGDTSEDASI 20 HRLEGTDLDC 30 QVGGLICKSK 40 SAASEQHVFK 50 APAPRPSLLG 60 LDLLASLKRR 70 EREEKDDGED 80 KKKSKVSSYK 90 DWEESKDDQK 100 DAEEEGGDQA 110 GQNIRKDRHY 120 RSARVETPSH 130 PGGVSEEFWE 140 RSRQRERERR 150 EHGVYASSKE 160 EKDWKKEKSR 170 DRDYDRKRDR 180 DERDRSRHSS 190 RSERDGGSER 200 SSRRNEPESP 210 RHRPKDAATP 220 SRSTWEEEDS 230 GYGSSRRSQW 240 ESPSPTPSYR 250 DSERSHRLST 260 RDRDRSVRGK 270 YSDDTPLPTP 280 SYKYNEWADD 290 RRHLGSTPRL 300 SRGRGRREEG 310 EEGISFDTEE 320 ERQQWEDDQR 330 QADRDWYMMD 340 EGYDEFHNPL 350 AYSSEDYVRR 360 REQHLHKQKQ 370 KRISAQRRQI 380 NEDNERWETN 390 RMLTSGVVHR 400 LEVDEDFEED 410 NAAKVHLMVH 420 NLVPPFLDGR 430 IVFTKQPEPV 440 IPVKDATSDL 450 AIIARKGSQT 460 VRKHREQKER 470 KKAQHKHWEL 480 AGTKLGDIMG 490 VKKEEEPDKA 500 VTEDGKVDYR 510 TEQKFADHMK 520 RKSEASSEFA 530 KKKSILEQRQ 540 YLPIFAVQQE 550 LLTIIRDNSI 560 VIVVGETGSG 570 KTTQLTQYLH 580 EDGYTDYGMI 590 GCTQPRRVAA 600 MSVAKRVSEE 610 MGGNLGEEVG 620 YAIRFEDCTS 630 ENTLIKYMTD 640 GILLRESLRE 650 ADLDHYSAII 660 MDEAHERSLN 670 TDVLFGLLRE 680 VVARRSDLKL 690 IVTSATMDAE 700 KFAAFFGNVP 710 IFHIPGRTFP 720 VDILFSKTPQ 730 EDYVEAAVKQ 740 SLQVHLSGAP 750 GDILIFMPGQ 760 EDIEVTSDQI 770 VEHLEELENA 780 PALAVLPIYS 790 QLPSDLQAKI 800 FQKAPDGVRK 810 CIVATNIAET 820 SLTVDGIMFV 830 IDSGYCKLKV 840 FNPRIGMDAL 850 QIYPISQANA 860 NQRSGRAGRT 870 GPGQCFRLYT 880 QSAYKNELLT 890 TTVPEIQRTN 900 LANVVLLLKS 910 LGVQDLLQFH 920 FMDPPPEDNM 930 LNSMYQLWIL 940 GALDNTGGLT 950 STGRLMVEFP 960 LDPALSKMLI 970 VSCDMGCSSE 980 ILLIVSMLSV 990 PAIFYRPKGR 1000 EEESDQIREK 1010 FAVPESDHLT 1020 YLNVYLQWKN 1030 NNYSTIWCND 1040 HFIHAKAMRK 1050 VREVRAQLKD 1060 IMVQQRMSLA 1070 SCGTDWDIVR 1080 KCICAAYFHQ 1090 AAKLKGIGEY 1100 VNIRTGMPCH 1110 LHPTSSLFGM 1120 GYTPDYIVYH 1130 ELVMTTKEYM 1140 QCVTAVDGEW 1150 LAELGPMFYS 1160 VKQAGKSRQE 1170 NRRRAKEEAS 1180 AMEEEMALAE 1190 EQLRARRQEQ 1200 EKRSPLGSVR 1210 STKIYTPGRK 1220 EQGEPMTPRR TPARFGL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0034458 3'-5' RNA helicase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003724 RNA helicase activity
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.