Search Results
Overview
| Uniprot ID | Q92637 |
|---|---|
| Protein Name | Putative high affinity immunoglobulin gamma Fc receptor IB |
| Gene Name | FCGR1BP |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 242 | LDSGHEKKVISSLQE |
Function
May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response
Protein Sequence
10
MWFLTTLLLW
20
VPVDGQVDTT
30
KAVITLQPPW
40
VSVFQEETVT
50
LHCEVLHLPG
60
SSSTQWFLNG
70
TATQTSTPSY
80
RITSASVNDS
90
GEYRCQRGLS
100
GRSDPIQLEI
110
HRGWLLLQVS
120
SRVFMEGEPL
130
ALRCHAWKDK
140
LVYNVLYYRN
150
GKAFKFFHWN
160
SNLTILKTNI
170
SHNGTYHCSG
180
MGKHRYTSAG
190
ISQYTVKGLQ
200
LPTPVWFHVL
210
FYLAVGIMFL
220
VNTVLWVTIR
230
KELKRKKKWN
240
LEISLDSGHE
250
KKVISSLQED
260
RHLEEELKCQ
270
EQKEEQLQEG
280
VHRKEPQGAT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0009897 | external side of plasma membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0019864 | IgG binding |
| Molecular Function | GO:0019770 | IgG receptor activity |
| Molecular Function | GO:0019763 | immunoglobulin receptor activity |
| Biological Process | GO:0001788 | antibody-dependent cellular cytotoxicity |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0006955 | immune response |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.