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Overview

Uniprot IDQ92667
Protein NameA-kinase anchor protein 1, mitochondrial
Gene NameAKAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
160 KGVLFSSKSAEVCKQ
177 PFSRVPRKVQPGYPV
589 DSCCSLKKTESFQNA

Function

Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane (By similarity). Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity (By similarity)

Protein Sequence

10 MAIQFRSLFP 20 LALPGMLALL 30 GWWWFFSRKK 40 GHVSSHDEQQ 50 VEAGAVQLRA 60 DPAIKEPLPV 70 EDVCPKVVST 80 PPSVTEPPEK 90 ELSTVSKLPA 100 EPPALLQTHP 110 PCRRSESSGI 120 LPNTTDMRLR 130 PGTRRDDSTK 140 LELALTGGEA 150 KSIPLECPLS 160 SPKGVLFSSK 170 SAEVCKQDSP 180 FSRVPRKVQP 190 GYPVVPAEKR 200 SSGERARETG 210 GAEGTGDAVL 220 GEKVLEEALL 230 SREHVLELEN 240 SKGPSLASLE 250 GEEDKGKSSS 260 SQVVGPVQEE 270 EYVAEKLPSR 280 FIESAHTELA 290 KDDAAPAPPV 300 ADAKAQDRGV 310 EGELGNEESL 320 DRNEEGLDRN 330 EEGLDRNEES 340 LDRNEEGLDR 350 NEEIKRAAFQ 360 IISQVISEAT 370 EQVLATTVGK 380 VAGRVCQASQ 390 LQGQKEESCV 400 PVHQKTVLGP 410 DTAEPATAEA 420 AVAPPDAGLP 430 LPGLPAEGSP 440 PPKTYVSCLK 450 SLLSSPTKDS 460 KPNISAHHIS 470 LASCLALTTP 480 SEELPDRAGI 490 LVEDATCVTC 500 MSDSSQSVPL 510 VASPGHCSDS 520 FSTSGLEDSC 530 TETSSSPRDK 540 AITPPLPEST 550 VPFSNGVLKG 560 ELSDLGAEDG 570 WTMDAEADHS 580 GGSDRNSMDS 590 VDSCCSLKKT 600 ESFQNAQAGS 610 NPKKVDLIIW 620 EIEVPKHLVG 630 RLIGKQGRYV 640 SFLKQTSGAK 650 IYISTLPYTQ 660 SVQICHIEGS 670 QHHVDKALNL 680 IGKKFKELNL 690 TNIYAPPLPS 700 LALPSLPMTS 710 WLMLPDGITV 720 EVIVVNQVNA 730 GHLFVQQHTH 740 PTFHALRSLD 750 QQMYLCYSQP 760 GIPTLPTPVE 770 ITVICAAPGA 780 DGAWWRAQVV 790 ASYEETNEVE 800 IRYVDYGGYK 810 RVKVDVLRQI 820 RSDFVTLPFQ 830 GAEVLLDSVM 840 PLSDDDQFSP 850 EADAAMSEMT 860 GNTALLAQVT 870 SYSPTGLPLI 880 QLWSVVGDEV 890 VLINRSLVER 900 GLAQWVDSYY TSL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0034237 protein kinase A regulatory subunit binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0140374 antiviral innate immune response
Biological Process GO:0006915 apoptotic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.