Search Results
Overview
| Uniprot ID | Q92674 |
|---|---|
| Protein Name | Centromere protein I |
| Gene Name | CENPI |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 301 | PANVRPLKRKWNSLS |
| 40 | KQDPSNSKNISKHGQ |
| 625 | KKNELVQKTKSEFNF |
Function
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone
Protein Sequence
10
MSPQKRVKNV
20
QAQNRTSQGS
30
SSFQTTLSAW
40
KVKQDPSNSK
50
NISKHGQNNP
60
VGDYEHADDQ
70
AEEDALQMAV
80
GYFEKGPIKA
90
SQNKDKTLEK
100
HLKTVENVAW
110
KNGLASEEID
120
ILLNIALSGK
130
FGNAVNTRIL
140
KCMIPATVIS
150
EDSVVKAVSW
160
LCVGKCSGST
170
KVLFYRWLVA
180
MFDFIDRKEQ
190
INLLYGFFFA
200
SLQDDALCPY
210
VCHLLYLLTK
220
KENVKPFRVR
230
KLLDLQAKMG
240
MQPHLQALLS
250
LYKFFAPALI
260
SVSLPVRKKI
270
YFKNSENLWK
280
TALLAVKQRN
290
RGPSPEPLKL
300
MLGPANVRPL
310
KRKWNSLSVI
320
PVLNSSSYTK
330
ECGKKEMSLS
340
DCLNRSGSFP
350
LEQLQSFPQL
360
LQNIHCLELP
370
SQMGSVLNNS
380
LLLHYINCVR
390
DEPVLLRFYY
400
WLSQTLQEEC
410
IWYKVNNYEH
420
GKEFTNFLDT
430
IIRAECFLQE
440
GFYSCEAFLY
450
KSLPLWDGLC
460
CRSQFLQLVS
470
WIPFSSFSEV
480
KPLLFDHLAQ
490
LFFTSTIYFK
500
CSVLQSLKEL
510
LQNWLLWLSM
520
DIHMKPVTNS
530
PLETTLGGSM
540
NSVSKLIHYV
550
GWLSTTAMRL
560
ESNNTFLLHF
570
ILDFYEKVCD
580
IYINYNLPLV
590
VLFPPGIFYS
600
ALLSLDTSIL
610
NQLCFIMHRY
620
RKNLTAAKKN
630
ELVQKTKSEF
640
NFSSKTYQEF
650
NHYLTSMVGC
660
LWTSKPFGKG
670
IYIDPEILEK
680
TGVAEYKNSL
690
NVVHHPSFLS
700
YAVSFLLQES
710
PEERTVNVSS
720
IRGKKWSWYL
730
DYLFSQGLQG
740
LKLFIRSSVH
750
HSSIPRAEGI
NCNNQY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000939 | inner kinetochore |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0034080 | CENP-A containing chromatin assembly |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0000070 | mitotic sister chromatid segregation |
| Biological Process | GO:0007548 | sex differentiation |
Reference
PMID: N/A