Search Results
Overview
| Uniprot ID | Q92686 |
|---|---|
| Protein Name | Neurogranin |
| Gene Name | NRGN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 54 | KSGERGRKGPGPGGP |
Function
Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity)
Protein Sequence
10
MDCCTENACS
20
KPDDDILDIP
30
LDDPGANAAA
40
AKIQASFRGH
50
MARKKIKSGE
60
RGRKGPGPGG
70
PGGAGVARGG
AGGGPSGD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0044327 | dendritic spine head |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0012510 | trans-Golgi network transport vesicle membrane |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0070300 | phosphatidic acid binding |
| Molecular Function | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| Biological Process | GO:0008306 | associative learning |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:1900273 | positive regulation of long-term synaptic potentiation |
| Biological Process | GO:0099170 | postsynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0021537 | telencephalon development |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.