Search Results

Overview

Uniprot ID	Q92688
Protein Name	Acidic leucine-rich nuclear phosphoprotein 32 family member B
Gene Name	ANP32B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
101	NLSGNKLKDISTLEP
110	ISTLEPLKKLECLKS
28	ELVLDNCKSNDGKIE
68	PKLPKLKKLELSENR
99	HLNLSGNKLKDISTL

Function

Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864). Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:18039846, PubMed:20538007). Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712). Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity)

Protein Sequence

10 MDMKRRIHLE 20 LRNRTPAAVR 30 ELVLDNCKSN 40 DGKIEGLTAE 50 FVNLEFLSLI 60 NVGLISVSNL 70 PKLPKLKKLE 80 LSENRIFGGL 90 DMLAEKLPNL 100 THLNLSGNKL 110 KDISTLEPLK 120 KLECLKSLDL 130 FNCEVTNLND 140 YRESVFKLLP 150 QLTYLDGYDR 160 EDQEAPDSDA 170 EVDGVDEEEE 180 DEEGEDEEDE 190 DDEDGEEEEF 200 DEEDDEDEDV 210 EGDEDDDEVS 220 EEEEEFGLDE 230 EDEDEDEDEE 240 EEEGGKGEKR 250 KRETDDEGED D

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0042393	histone binding
Molecular Function	GO:0070063	RNA polymerase binding
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0045596	negative regulation of cell differentiation
Biological Process	GO:0006334	nucleosome assembly
Biological Process	GO:0046827	positive regulation of protein export from nucleus
Biological Process	GO:0042981	regulation of apoptotic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.