Search Results
Overview
| Uniprot ID | Q92692 |
|---|---|
| Protein Name | Nectin-2 |
| Gene Name | NECTIN2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | LRVIAKPKNQAEAQK |
Function
Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005)
Protein Sequence
10
MARAAALLPS
20
RSPPTPLLWP
30
LLLLLLLETG
40
AQDVRVQVLP
50
EVRGQLGGTV
60
ELPCHLLPPV
70
PGLYISLVTW
80
QRPDAPANHQ
90
NVAAFHPKMG
100
PSFPSPKPGS
110
ERLSFVSAKQ
120
STGQDTEAEL
130
QDATLALHGL
140
TVEDEGNYTC
150
EFATFPKGSV
160
RGMTWLRVIA
170
KPKNQAEAQK
180
VTFSQDPTTV
190
ALCISKEGRP
200
PARISWLSSL
210
DWEAKETQVS
220
GTLAGTVTVT
230
SRFTLVPSGR
240
ADGVTVTCKV
250
EHESFEEPAL
260
IPVTLSVRYP
270
PEVSISGYDD
280
NWYLGRTDAT
290
LSCDVRSNPE
300
PTGYDWSTTS
310
GTFPTSAVAQ
320
GSQLVIHAVD
330
SLFNTTFVCT
340
VTNAVGMGRA
350
EQVIFVRETP
360
NTAGAGATGG
370
IIGGIIAAII
380
ATAVAATGIL
390
ICRQQRKEQT
400
LQGAEEDEDL
410
EGPPSYKPPT
420
PKAKLEAQEM
430
PSQLFTLGAS
440
EHSPLKTPYF
450
DAGASCTEQE
460
MPRYHELPTL
470
EERSGPLHPG
480
ATSLGSPIPV
490
PPGPPAVEDV
500
SLDLEDEEGE
510
EEEEYLDKIN
520
PIYDALSYSS
530
PSDSYQGKGF
VMSRAMYV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005915 | zonula adherens |
| Cellular Component | GO:0043296 | apical junction complex |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0044291 | cell-cell contact zone |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0050839 | cell adhesion molecule binding |
| Molecular Function | GO:0015026 | coreceptor activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0001618 | virus receptor activity |
| Biological Process | GO:0044406 | adhesion of symbiont to host |
| Biological Process | GO:0046814 | coreceptor-mediated virion attachment to host cell |
| Biological Process | GO:0019064 | fusion of virus membrane with host plasma membrane |
| Biological Process | GO:0007156 | homophilic cell-cell adhesion |
| Biological Process | GO:0042267 | natural killer cell mediated cytotoxicity |
| Biological Process | GO:0045953 | negative regulation of natural killer cell mediated cytotoxicity |
| Biological Process | GO:0002891 | positive regulation of immunoglobulin mediated immune response |
| Biological Process | GO:0033005 | positive regulation of mast cell activation |
| Biological Process | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity |
| Biological Process | GO:0002860 | positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target |
| Biological Process | GO:0050862 | positive regulation of T cell receptor signaling pathway |
| Biological Process | GO:0046596 | regulation of viral entry into host cell |
| Biological Process | GO:0007286 | spermatid development |
| Biological Process | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity |
| Biological Process | GO:0060370 | susceptibility to T cell mediated cytotoxicity |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.