Search Results

Overview

Uniprot IDQ92733
Protein NameProline-rich protein PRCC
Gene NamePRCC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
139 PLGLPKPKKRKEPVK
140 LGLPKPKKRKEPVKI
146 KKRKEPVKIAAPELH
207 LPHAFSRKPSDGSPD
225 SRLASKTKTSSLAPV
246 TPSPSAIKAAAKSAA
250 SAIKAAAKSAALQVT
434 TKSLTEEKTMKSFSK
443 MKSFSKKKGEQPTGQ
454 PTGQQRRKHQITYLI
472 KERELELKNTWSENK
479 KNTWSENKLSRRQTQ

Function

May regulate cell cycle progression through interaction with MAD2L2

Protein Sequence

10 MSLVAYASSD 20 ESEPDEAEPE 30 PEEEEAVAPT 40 SGPALGGLFA 50 SLPAPKGPAL 60 LPPPPQMLAP 70 AFPPPLLLPP 80 PTGDPRLQPP 90 PPLPFGLGGF 100 PPPPGVSPAE 110 AAGVGEGLGL 120 GLPSPRGPGL 130 NLPPPIGGAG 140 PPLGLPKPKK 150 RKEPVKIAAP 160 ELHKGDSDSE 170 EDEPTKKKTI 180 LQGSSEGTGL 190 SALLPQPKNL 200 TVKETNRLLL 210 PHAFSRKPSD 220 GSPDTKPSRL 230 ASKTKTSSLA 240 PVVGTTTTTP 250 SPSAIKAAAK 260 SAALQVTKQI 270 TQEEDDSDEE 280 VAPENFFSLP 290 EKAEPPGVEP 300 YPYPIPTVPE 310 ELPPGTEPEP 320 AFQDDAANAP 330 LEFKMAAGSS 340 GAPWMPKPGD 350 DYSYNQFSTY 360 GDANAAGAYY 370 QDYYSGGYYP 380 AQDPALVPPQ 390 EIAPDASFID 400 DEAFKRLQGK 410 RNRGREEINF 420 VEIKGDDQLS 430 GAQQWMTKSL 440 TEEKTMKSFS 450 KKKGEQPTGQ 460 QRRKHQITYL 470 IHQAKERELE 480 LKNTWSENKL 490 SRRQTQAKYG F

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Biological Process GO:0051726 regulation of cell cycle

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.