Search Results
Overview
| Uniprot ID | Q92734 |
|---|---|
| Protein Name | Protein TFG |
| Gene Name | TFG |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | PLESSQVKYLRRELI |
| 47 | MQRVFRGKLLSNDEV |
Function
Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858)
Protein Sequence
10
MNGQLDLSGK
20
LIIKAQLGED
30
IRRIPIHNED
40
ITYDELVLMM
50
QRVFRGKLLS
60
NDEVTIKYKD
70
EDGDLITIFD
80
SSDLSFAIQC
90
SRILKLTLFV
100
NGQPRPLESS
110
QVKYLRRELI
120
ELRNKVNRLL
130
DSLEPPGEPG
140
PSTNIPENDT
150
VDGREEKSAS
160
DSSGKQSTQV
170
MAASMSAFDP
180
LKNQDEINKN
190
VMSAFGLTDD
200
QVSGPPSAPA
210
EDRSGTPDSI
220
ASSSSAAHPP
230
GVQPQQPPYT
240
GAQTQAGQIE
250
GQMYQQYQQQ
260
AGYGAQQPQA
270
PPQQPQQYGI
280
QYSASYSQQT
290
GPQQPQQFQG
300
YGQQPTSQAP
310
APAFSGQPQQ
320
LPAQPPQQYQ
330
ASNYPAQTYT
340
AQTSQPTNYT
350
VAPASQPGMA
360
PSQPGAYQPR
370
PGFTSLPGST
380
MTPPPSGPNP
390
YARNRPPFGQ
400
GYTQPGPGYR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070971 | endoplasmic reticulum exit site |
| Molecular Function | GO:0042802 | identical protein binding |
| Biological Process | GO:0048208 | COPII vesicle coating |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.