Search Results
Overview
| Uniprot ID | Q92747 |
|---|---|
| Protein Name | Actin-related protein 2/3 complex subunit 1A |
| Gene Name | ARPC1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | NRAATFVKWSPLENK |
| 36 | NHEVHIYKKNGSQWV |
Function
Probably functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks
Protein Sequence
10
MSLHQFLLEP
20
ITCHAWNRDR
30
TQIALSPNNH
40
EVHIYKKNGS
50
QWVKAHELKE
60
HNGHITGIDW
70
APKSDRIVTC
80
GADRNAYVWS
90
QKDGVWKPTL
100
VILRINRAAT
110
FVKWSPLENK
120
FAVGSGARLI
130
SVCYFESEND
140
WWVSKHIKKP
150
IRSTVLSLDW
160
HPNNVLLAAG
170
SCDFKCRVFS
180
AYIKEVDEKP
190
ASTPWGSKMP
200
FGQLMSEFGG
210
SGTGGWVHGV
220
SFSASGSRLA
230
WVSHDSTVSV
240
ADASKSVQVS
250
TLKTEFLPLL
260
SVSFVSENSV
270
VAAGHDCCPM
280
LFNYDDRGCL
290
TFVSKLDIPK
300
QSIQRNMSAM
310
ERFRNMDKRA
320
TTEDRNTALE
330
TLHQNSITQV
340
SIYEVDKQDC
350
RKFCTTGIDG
360
AMTIWDFKTL
370
ESSIQGLRIM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005885 | Arp2/3 protein complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0036195 | muscle cell projection membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035861 | site of double-strand break |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0051015 | actin filament binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0034314 | Arp2/3 complex-mediated actin nucleation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.