Search Results

Overview

Uniprot ID	Q92752
Protein Name	Tenascin-R
Gene Name	TNR
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
530	EWIPPRAKVDFILLK

Function

Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity)

Protein Sequence

10 MGADGETVVL 20 KNMLIGINLI 30 LLGSMIKPSE 40 CQLEVTTERV 50 QRQSVEEEGG 60 IANYNTSSKE 70 QPVVFNHVYN 80 INVPLDNLCS 90 SGLEASAEQE 100 VSAEDETLAE 110 YMGQTSDHES 120 QVTFTHRINF 130 PKKACPCASS 140 AQVLQELLSR 150 IEMLEREVSV 160 LRDQCNANCC 170 QESAATGQLD 180 YIPHCSGHGN 190 FSFESCGCIC 200 NEGWFGKNCS 210 EPYCPLGCSS 220 RGVCVDGQCI 230 CDSEYSGDDC 240 SELRCPTDCS 250 SRGLCVDGEC 260 VCEEPYTGED 270 CRELRCPGDC 280 SGKGRCANGT 290 CLCEEGYVGE 300 DCGQRQCLNA 310 CSGRGQCEEG 320 LCVCEEGYQG 330 PDCSAVAPPE 340 DLRVAGISDR 350 SIELEWDGPM 360 AVTEYVISYQ 370 PTALGGLQLQ 380 QRVPGDWSGV 390 TITELEPGLT 400 YNISVYAVIS 410 NILSLPITAK 420 VATHLSTPQG 430 LQFKTITETT 440 VEVQWEPFSF 450 SFDGWEISFI 460 PKNNEGGVIA 470 QVPSDVTSFN 480 QTGLKPGEEY 490 IVNVVALKEQ 500 ARSPPTSASV 510 STVIDGPTQI 520 LVRDVSDTVA 530 FVEWIPPRAK 540 VDFILLKYGL 550 VGGEGGRTTF 560 RLQPPLSQYS 570 VQALRPGSRY 580 EVSVSAVRGT 590 NESDSATTQF 600 TTEIDAPKNL 610 RVGSRTATSL 620 DLEWDNSEAE 630 VQEYKVVYST 640 LAGEQYHEVL 650 VPRGIGPTTR 660 ATLTDLVPGT 670 EYGVGISAVM 680 NSQQSVPATM 690 NARTELDSPR 700 DLMVTASSET 710 SISLIWTKAS 720 GPIDHYRITF 730 TPSSGIASEV 740 TVPKDRTSYT 750 LTDLEPGAEY 760 IISVTAERGR 770 QQSLESTVDA 780 FTGFRPISHL 790 HFSHVTSSSV 800 NITWSDPSPP 810 ADRLILNYSP 820 RDEEEEMMEV 830 SLDATKRHAV 840 LMGLQPATEY 850 IVNLVAVHGT 860 VTSEPIVGSI 870 TTGIDPPKDI 880 TISNVTKDSV 890 MVSWSPPVAS 900 FDYYRVSYRP 910 TQVGRLDSSV 920 VPNTVTEFTI 930 TRLNPATEYE 940 ISLNSVRGRE 950 ESERICTLVH 960 TAMDNPVDLI 970 ATNITPTEAL 980 LQWKAPVGEV 990 ENYVIVLTHF 1000 AVAGETILVD 1010 GVSEEFRLVD 1020 LLPSTHYTAT 1030 MYATNGPLTS 1040 GTISTNFSTL 1050 LDPPANLTAS 1060 EVTRQSALIS 1070 WQPPRAEIEN 1080 YVLTYKSTDG 1090 SRKELIVDAE 1100 DTWIRLEGLL 1110 ENTDYTVLLQ 1120 AAQDTTWSSI 1130 TSTAFTTGGR 1140 VFPHPQDCAQ 1150 HLMNGDTLSG 1160 VYPIFLNGEL 1170 SQKLQVYCDM 1180 TTDGGGWIVF 1190 QRRQNGQTDF 1200 FRKWADYRVG 1210 FGNVEDEFWL 1220 GLDNIHRITS 1230 QGRYELRVDM 1240 RDGQEAAFAS 1250 YDRFSVEDSR 1260 NLYKLRIGSY 1270 NGTAGDSLSY 1280 HQGRPFSTED 1290 RDNDVAVTNC 1300 AMSYKGAWWY 1310 KNCHRTNLNG 1320 KYGESRHSQG 1330 INWYHWKGHE 1340 FSIPFVEMKM 1350 RPYNHRLMAG RKRQSLQF

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0050804	modulation of chemical synaptic transmission
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0072534	perineuronal net
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse
Biological Process	GO:0007411	axon guidance
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0030155	regulation of cell adhesion
Biological Process	GO:0045595	regulation of cell differentiation
Biological Process	GO:0030334	regulation of cell migration

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.