Overview
| Uniprot ID | Q92759 |
|---|
| Protein Name | General transcription factor IIH subunit 4 |
|---|
| Gene Name | GTF2H4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 127 |
IALLGGGKAWSDDTS |
Function
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription
Protein Sequence
10
MESTPSRGLN
20
RVHLQCRNLQ
30
EFLGGLSPGV
40
LDRLYGHPAT
50
CLAVFRELPS
60
LAKNWVMRML
70
FLEQPLPQAA
80
VALWVKKEFS
90
KAQEESTGLL
100
SGLRIWHTQL
110
LPGGLQGLIL
120
NPIFRQNLRI
130
ALLGGGKAWS
140
DDTSQLGPDK
150
HARDVPSLDK
160
YAEERWEVVL
170
HFMVGSPSAA
180
VSQDLAQLLS
190
QAGLMKSTEP
200
GEPPCITSAG
210
FQFLLLDTPA
220
QLWYFMLQYL
230
QTAQSRGMDL
240
VEILSFLFQL
250
SFSTLGKDYS
260
VEGMSDSLLN
270
FLQHLREFGL
280
VFQRKRKSRR
290
YYPTRLAINL
300
SSGVSGAGGT
310
VHQPGFIVVE
320
TNYRLYAYTE
330
SELQIALIAL
340
FSEMLYRFPN
350
MVVAQVTRES
360
VQQAIASGIT
370
AQQIIHFLRT
380
RAHPVMLKQT
390
PVLPPTITDQ
400
IRLWELERDR
410
LRFTEGVLYN
420
QFLSQVDFEL
430
LLAHARELGV
440
LVFENSAKRL
450
MVVTPAGHSD
460
VKRFWKRQKH
SS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000438 |
core TFIIH complex portion of holo TFIIH complex |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005669 |
transcription factor TFIID complex |
| Cellular Component |
GO:0000439 |
transcription factor TFIIH core complex |
| Cellular Component |
GO:0005675 |
transcription factor TFIIH holo complex |
| Molecular Function |
GO:0001671 |
ATPase activator activity |
| Molecular Function |
GO:0003690 |
double-stranded DNA binding |
| Molecular Function |
GO:0016251 |
RNA polymerase II general transcription initiation factor activity |
| Biological Process |
GO:0006281 |
DNA repair |
| Biological Process |
GO:0006289 |
nucleotide-excision repair |
| Biological Process |
GO:0006366 |
transcription by RNA polymerase II |
| Biological Process |
GO:0006367 |
transcription initiation at RNA polymerase II promoter |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.