Search Results

Overview

Uniprot IDQ92766
Protein NameRas-responsive element-binding protein 1
Gene NameRREB1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1245 SYTNCLQKITCPHCP
1400 LACDTCGKSFKFLGT
1403 DTCGKSFKFLGTLSR
1506 SPKSVASKADKRKKV
1619 MAVTRSRKEGLASAT
1627 EGLASATKDCSHREE
190 EDPAPAKKMVEDGQS
551 PPPLKLLKGSVEAAS
566 NAHLLQSKSGTQPHA
63 NQETKEEKSSYNCPL
634 MTAPGGKKTPAMRKV
640 KKTPAMRKVLYPCRF

Function

Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters (PubMed:10390538, PubMed:15067362, PubMed:17550981, PubMed:8816445, PubMed:9305772). Represses the angiotensinogen gene (PubMed:15067362). Negatively regulates the transcriptional activity of AR (PubMed:17550981). Potentiates the transcriptional activity of NEUROD1 (PubMed:12482979). Promotes brown adipocyte differentiation (By similarity). May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression (PubMed:8816445)

Protein Sequence

10 MTSSSPAGLE 20 GSDLSSINTM 30 MSAVMSVGKV 40 TENGGSPQGI 50 KSPSKPPGPN 60 RIGRRNQETK 70 EEKSSYNCPL 80 CEKICTTQHQ 90 LTMHIRQHNT 100 DTGGADHSCS 110 ICGKSLSSAS 120 SLDRHMLVHS 130 GERPYKCTVC 140 GQSFTTNGNM 150 HRHMKIHEKD 160 PNSATATAPP 170 SPLKRRRLSS 180 KRKLSHDAES 190 EREDPAPAKK 200 MVEDGQSGDL 210 EKKADEVFHC 220 PVCFKEFVCK 230 YGLETHMETH 240 SDNPLRCDIC 250 CVTFRTHRGL 260 LRHNALVHKQ 270 LPRDAMGRPF 280 IQNNPSIPAG 290 FHDLGFTDFS 300 CRKFPRISQA 310 WCETNLRRCI 320 SEQHRFVCDT 330 CDKAFPMLCS 340 LALHKQTHVA 350 ADQGQEKPQA 360 TPLPGDALDQ 370 KGFLALLGLQ 380 HTKDVRPAPA 390 EEPLPDDNQA 400 IQLQTLKCQL 410 PQDPGCTNLL 420 SLSPFEAASL 430 GGSLTVLPAT 440 KDSIKHLSLQ 450 PFQKGFIIQP 460 DSSIVVKPIS 470 GESAIELADI 480 QQILKMAASA 490 PPQISLPPFS 500 KAPAAPLQAI 510 FKHMPPLKPK 520 PLVTPRTVVA 530 TSTPPPLINA 540 QQASPGCISP 550 SLPPPPLKLL 560 KGSVEAASNA 570 HLLQSKSGTQ 580 PHAATRLSLQ 590 QPRAELPGQP 600 EMKTQLEQDS 610 IIEALLPLSM 620 EAKIKQEITE 630 GELKAFMTAP 640 GGKKTPAMRK 650 VLYPCRFCNQ 660 VFAFSGVLRA 670 HVRSHLGISP 680 YQCNICDYIA 690 ADKAALIRHL 700 RTHSGERPYI 710 CKICHYPFTV 720 KANCERHLRK 730 KHLKATRKDI 740 EKNIEYVSSS 750 AAELVDAFCA 760 PDTVCRLCGE 770 DLKHYRALRI 780 HMRTHCGRGL 790 GGGHKGRKPF 800 ECKECSAAFA 810 AKRNCIHHIL 820 KQHLHVPEQD 830 IESYVLAADG 840 LGPAEAPAAE 850 ASGRGEDSGC 860 AALGDCKPLT 870 AFLEPQNGFL 880 HRGPTQPPPP 890 HVSIKLEPAS 900 SFAVDFNEPL 910 DFSQKGLALV 920 QVKQENISFL 930 SPSSLVPYDC 940 SMEPIDLSIP 950 KNFRKGDKDL 960 ATPSEAKKPE 970 EEAGSSEQPS 980 PCPAPGPSLP 990 VTLGPSGILE 1000 SPMAPAPAAT 1010 PEPPAQPLQG 1020 PVQLAVPIYS 1030 SALVSSPPLV 1040 GSSALLSGTA 1050 LLRPLRPKPP 1060 LLLPKPPVTE 1070 ELPPLASIAQ 1080 IISSVSSAPT 1090 LLKTKVADPG 1100 PASTGSNTTA 1110 SDSLGGSVPK 1120 AATTATPAAT 1130 TSPKESSEPP 1140 APASSPEAAS 1150 PTEQGPAGTS 1160 KKRGRKRGMR 1170 SRPRANSGGV 1180 DLDSSGEFAS 1190 IEKMLATTDT 1200 NKFSPFLQTA 1210 EDNTQDEVAG 1220 APADHHGPSD 1230 EEQGSPPEDK 1240 LLRAKRNSYT 1250 NCLQKITCPH 1260 CPRVFPWASS 1270 LQRHMLTHTD 1280 SQSDAETAAA 1290 AGEVLDLTSR 1300 DREQPSEGAT 1310 ELRQVAGDAP 1320 VEQATAETAS 1330 PVHREEHGRG 1340 ESHEPEEEHG 1350 TEESTGDADG 1360 AEEDASSNQS 1370 LDLDFATKLM 1380 DFKLAEGDGE 1390 AGAGGAASQE 1400 QKLACDTCGK 1410 SFKFLGTLSR 1420 HRKAHGRQEP 1430 KDEKGDGAST 1440 AEEGPQPAPE 1450 QEEKPPETPA 1460 EVVESAPGAG 1470 EAPAEKLAEE 1480 TEGPSDGESA 1490 AEKRSSEKSD 1500 DDKKPKTDSP 1510 KSVASKADKR 1520 KKVCSVCNKR 1530 FWSLQDLTRH 1540 MRSHTGERPY 1550 KCQTCERTFT 1560 LKHSLVRHQR 1570 IHQKARHAKH 1580 HGKDSDKEER 1590 GEEDSENEST 1600 HSGNNAVSEN 1610 EAELAPNASN 1620 HMAVTRSRKE 1630 GLASATKDCS 1640 HREEKVTAGW 1650 PSEPGQGDLN 1660 PESPAALGQD 1670 LLEPRSKRPA 1680 HPILATADGA SQLVGME

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005634 nucleus
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0090336 positive regulation of brown fat cell differentiation
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010634 positive regulation of epithelial cell migration
Biological Process GO:2000394 positive regulation of lamellipodium morphogenesis
Biological Process GO:0033601 positive regulation of mammary gland epithelial cell proliferation
Biological Process GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:1903691 positive regulation of wound healing, spreading of epidermal cells
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0006366 transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.