Overview
| Uniprot ID | Q92783 |
|---|
| Protein Name | Signal transducing adapter molecule 1 |
|---|
| Gene Name | STAM |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 162 |
ASPALVAKDPGTVAN |
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes
Protein Sequence
10
MPLFATNPFD
20
QDVEKATSEM
30
NTAEDWGLIL
40
DICDKVGQSR
50
TGPKDCLRSI
60
MRRVNHKDPH
70
VAMQALTLLG
80
ACVSNCGKIF
90
HLEVCSRDFA
100
SEVSNVLNKG
110
HPKVCEKLKA
120
LMVEWTDEFK
130
NDPQLSLISA
140
MIKNLKEQGV
150
TFPAIGSQAA
160
EQAKASPALV
170
AKDPGTVANK
180
KEEEDLAKAI
190
ELSLKEQRQQ
200
STTLSTLYPS
210
TSSLLTNHQH
220
EGRKVRAIYD
230
FEAAEDNELT
240
FKAGEIITVL
250
DDSDPNWWKG
260
ETHQGIGLFP
270
SNFVTADLTA
280
EPEMIKTEKK
290
TVQFSDDVQV
300
ETIEPEPEPA
310
FIDEDKMDQL
320
LQMLQSTDPS
330
DDQPDLPELL
340
HLEAMCHQMG
350
PLIDEKLEDI
360
DRKHSELSEL
370
NVKVMEALSL
380
YTKLMNEDPM
390
YSMYAKLQNQ
400
PYYMQSSGVS
410
GSQVYAGPPP
420
SGAYLVAGNA
430
QMSHLQSYSL
440
PPEQLSSLSQ
450
AVVPPSANPA
460
LPSQQTQAAY
470
PNTMVSSVQG
480
NTYPSQAPVY
490
SPPPAATAAA
500
ATADVTLYQN
510
AGPNMPQVPN
520
YNLTSSTLPQ
530
PGGSQQPPQP
540
QQPYSQKALL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0033565 |
ESCRT-0 complex |
| Molecular Function |
GO:0035091 |
phosphatidylinositol binding |
| Molecular Function |
GO:0043130 |
ubiquitin binding |
| Molecular Function |
GO:0044389 |
ubiquitin-like protein ligase binding |
| Biological Process |
GO:0016236 |
macroautophagy |
| Biological Process |
GO:0090148 |
membrane fission |
| Biological Process |
GO:0036258 |
multivesicular body assembly |
| Biological Process |
GO:1903543 |
positive regulation of exosomal secretion |
| Biological Process |
GO:0043328 |
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| Biological Process |
GO:1903551 |
regulation of extracellular exosome assembly |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.