Search Results
Overview
| Uniprot ID | Q92786 |
|---|---|
| Protein Name | Prospero homeobox protein 1 |
| Gene Name | PROX1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 212 | RENKRKQKLPQQQQQ |
Function
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3
Protein Sequence
10
MPDHDSTALL
20
SRQTKRRRVD
30
IGVKRTVGTA
40
SAFFAKARAT
50
FFSAMNPQGS
60
EQDVEYSVVQ
70
HADGEKSNVL
80
RKLLKRANSY
90
EDAMMPFPGA
100
TIISQLLKNN
110
MNKNGGTEPS
120
FQASGLSSTG
130
SEVHQEDICS
140
NSSRDSPPEC
150
LSPFGRPTMS
160
QFDMDRLCDE
170
HLRAKRARVE
180
NIIRGMSHSP
190
SVALRGNENE
200
REMAPQSVSP
210
RESYRENKRK
220
QKLPQQQQQS
230
FQQLVSARKE
240
QKREERRQLK
250
QQLEDMQKQL
260
RQLQEKFYQI
270
YDSTDSENDE
280
DGNLSEDSMR
290
SEILDARAQD
300
SVGRSDNEMC
310
ELDPGQFIDR
320
ARALIREQEM
330
AENKPKREGN
340
NKERDHGPNS
350
LQPEGKHLAE
360
TLKQELNTAM
370
SQVVDTVVKV
380
FSAKPSRQVP
390
QVFPPLQIPQ
400
ARFAVNGENH
410
NFHTANQRLQ
420
CFGDVIIPNP
430
LDTFGNVQMA
440
SSTDQTEALP
450
LVVRKNSSDQ
460
SASGPAAGGH
470
HQPLHQSPLS
480
ATTGFTTSTF
490
RHPFPLPLMA
500
YPFQSPLGAP
510
SGSFSGKDRA
520
SPESLDLTRD
530
TTSLRTKMSS
540
HHLSHHPCSP
550
AHPPSTAEGL
560
SLSLIKSECG
570
DLQDMSEISP
580
YSGSAMQEGL
590
SPNHLKKAKL
600
MFFYTRYPSS
610
NMLKTYFSDV
620
KFNRCITSQL
630
IKWFSNFREF
640
YYIQMEKYAR
650
QAINDGVTST
660
EELSITRDCE
670
LYRALNMHYN
680
KANDFEVPER
690
FLEVAQITLR
700
EFFNAIIAGK
710
DVDPSWKKAI
720
YKVICKLDSE
730
VPEIFKSPNC
LQELLHE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0050692 | DNA binding domain binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0050693 | LBD domain binding |
| Molecular Function | GO:0016922 | nuclear receptor binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Biological Process | GO:0060414 | aorta smooth muscle tissue morphogenesis |
| Biological Process | GO:0055009 | atrial cardiac muscle tissue morphogenesis |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0021707 | cerebellar granule cell differentiation |
| Biological Process | GO:0007623 | circadian rhythm |
| Biological Process | GO:0021542 | dentate gyrus development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0021516 | dorsal spinal cord development |
| Biological Process | GO:0060059 | embryonic retina morphogenesis in camera-type eye |
| Biological Process | GO:0060214 | endocardium formation |
| Biological Process | GO:0070365 | hepatocyte differentiation |
| Biological Process | GO:0001822 | kidney development |
| Biological Process | GO:0002088 | lens development in camera-type eye |
| Biological Process | GO:0070309 | lens fiber cell morphogenesis |
| Biological Process | GO:0046619 | lens placode formation involved in camera-type eye formation |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0001946 | lymphangiogenesis |
| Biological Process | GO:0060836 | lymphatic endothelial cell differentiation |
| Biological Process | GO:0060838 | lymphatic endothelial cell fate commitment |
| Biological Process | GO:0070858 | negative regulation of bile acid biosynthetic process |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045071 | negative regulation of viral genome replication |
| Biological Process | GO:0021915 | neural tube development |
| Biological Process | GO:0097150 | neuronal stem cell population maintenance |
| Biological Process | GO:0030910 | olfactory placode formation |
| Biological Process | GO:0043049 | otic placode formation |
| Biological Process | GO:0031016 | pancreas development |
| Biological Process | GO:0045787 | positive regulation of cell cycle |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0010595 | positive regulation of endothelial cell migration |
| Biological Process | GO:0001938 | positive regulation of endothelial cell proliferation |
| Biological Process | GO:2000979 | positive regulation of forebrain neuron differentiation |
| Biological Process | GO:0060421 | positive regulation of heart growth |
| Biological Process | GO:2000179 | positive regulation of neural precursor cell proliferation |
| Biological Process | GO:0060298 | positive regulation of sarcomere organization |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway |
| Biological Process | GO:0042752 | regulation of circadian rhythm |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0031667 | response to nutrient levels |
| Biological Process | GO:0060042 | retina morphogenesis in camera-type eye |
| Biological Process | GO:0030240 | skeletal muscle thin filament assembly |
| Biological Process | GO:0048845 | venous blood vessel morphogenesis |
| Biological Process | GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
| Biological Process | GO:0055005 | ventricular cardiac myofibril assembly |
| Biological Process | GO:0060412 | ventricular septum morphogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.