Search Results

Overview

Uniprot IDQ92794
Protein NameHistone acetyltransferase KAT6A
Gene NameKAT6A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1147 PDTSTPLKKKKGWPK
405 VSLKFNKKTKGLIDG
848 VSSTRLSKQVLPHDS

Function

Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro) (PubMed:11742995, PubMed:11965546). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:11965546). May act as a transcriptional coactivator for RUNX1 and RUNX2 (PubMed:12771199). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (PubMed:23431171). May play a role in leukemogenic gene transcription (PubMed:39794553)

Protein Sequence

10 MVKLANPLYT 20 EWILEAIKKV 30 KKQKQRPSEE 40 RICNAVSSSH 50 GLDRKTVLEQ 60 LELSVKDGTI 70 LKVSNKGLNS 80 YKDPDNPGRI 90 ALPKPRNHGK 100 LDNKQNVDWN 110 KLIKRAVEGL 120 AESGGSTLKS 130 IERFLKGQKD 140 VSALFGGSAA 150 SGFHQQLRLA 160 IKRAIGHGRL 170 LKDGPLYRLN 180 TKATNVDGKE 190 SCESLSCLPP 200 VSLLPHEKDK 210 PVAEPIPICS 220 FCLGTKEQNR 230 EKKPEELISC 240 ADCGNSGHPS 250 CLKFSPELTV 260 RVKALRWQCI 270 ECKTCSSCRD 280 QGKNADNMLF 290 CDSCDRGFHM 300 ECCDPPLTRM 310 PKGMWICQIC 320 RPRKKGRKLL 330 QKKAAQIKRR 340 YTNPIGRPKN 350 RLKKQNTVSK 360 GPFSKVRTGP 370 GRGRKRKITL 380 SSQSASSSSE 390 EGYLERIDGL 400 DFCRDSNVSL 410 KFNKKTKGLI 420 DGLTKFFTPS 430 PDGRKARGEV 440 VDYSEQYRIR 450 KRGNRKSSTS 460 DWPTDNQDGW 470 DGKQENEERL 480 FGSQEIMTEK 490 DMELFRDIQE 500 QALQKVGVTG 510 PPDPQVRCPS 520 VIEFGKYEIH 530 TWYSSPYPQE 540 YSRLPKLYLC 550 EFCLKYMKSR 560 TILQQHMKKC 570 GWFHPPANEI 580 YRKNNISVFE 590 VDGNVSTIYC 600 QNLCLLAKLF 610 LDHKTLYYDV 620 EPFLFYVLTQ 630 NDVKGCHLVG 640 YFSKEKHCQQ 650 KYNVSCIMIL 660 PQYQRKGYGR 670 FLIDFSYLLS 680 KREGQAGSPE 690 KPLSDLGRLS 700 YMAYWKSVIL 710 ECLYHQNDKQ 720 ISIKKLSKLT 730 GICPQDITST 740 LHHLRMLDFR 750 SDQFVIIRRE 760 KLIQDHMAKL 770 QLNLRPVDVD 780 PECLRWTPVI 790 VSNSVVSEEE 800 EEEAEEGENE 810 EPQCQERELE 820 ISVGKSVSHE 830 NKEQDSYSVE 840 SEKKPEVMAP 850 VSSTRLSKQV 860 LPHDSLPANS 870 QPSRRGRWGR 880 KNRKTQERFG 890 DKDSKLLLEE 900 TSSAPQEQYG 910 ECGEKSEATQ 920 EQYTESEEQL 930 VASEEQPSQD 940 GKPDLPKRRL 950 SEGVEPWRGQ 960 LKKSPEALKC 970 RLTEGSERLP 980 RRYSEGDRAV 990 LRGFSESSEE 1000 EEEPESPRSS 1010 SPPILTKPTL 1020 KRKKPFLHRR 1030 RRVRKRKHHN 1040 SSVVTETISE 1050 TTEVLDEPFE 1060 DSDSERPMPR 1070 LEPTFEIDEE 1080 EEEEDENELF 1090 PREYFRRLSS 1100 QDVLRCQSSS 1110 KRKSKDEEED 1120 EESDDADDTP 1130 ILKPVSLLRK 1140 RDVKNSPLEP 1150 DTSTPLKKKK 1160 GWPKGKSRKP 1170 IHWKKRPGRK 1180 PGFKLSREIM 1190 PVSTQACVIE 1200 PIVSIPKAGR 1210 KPKIQESEET 1220 VEPKEDMPLP 1230 EERKEEEEMQ 1240 AEAEEAEEGE 1250 EEDAASSEVP 1260 AASPADSSNS 1270 PETETKEPEV 1280 EEEEEKPRVS 1290 EEQRQSEEEQ 1300 QELEEPEPEE 1310 EEDAAAETAQ 1320 NDDHDADDED 1330 DGHLESTKKK 1340 ELEEQPTRED 1350 VKEEPGVQES 1360 FLDANMQKSR 1370 EKIKDKEETE 1380 LDSEEEQPSH 1390 DTSVVSEQMA 1400 GSEDDHEEDS 1410 HTKEELIELK 1420 EEEEIPHSEL 1430 DLETVQAVQS 1440 LTQEESSEHE 1450 GAYQDCEETL 1460 AACQTLQSYT 1470 QADEDPQMSM 1480 VEDCHASEHN 1490 SPISSVQSHP 1500 SQSVRSVSSP 1510 NVPALESGYT 1520 QISPEQGSLS 1530 APSMQNMETS 1540 PMMDVPSVSD 1550 HSQQVVDSGF 1560 SDLGSIESTT 1570 ENYENPSSYD 1580 STMGGSICGN 1590 SSSQSSCSYG 1600 GLSSSSSLTQ 1610 SSCVVTQQMA 1620 SMGSSCSMMQ 1630 QSSVQPAANC 1640 SIKSPQSCVV 1650 ERPPSNQQQQ 1660 PPPPPPQQPQ 1670 PPPPQPQPAP 1680 QPPPPQQQPQ 1690 QQPQPQPQQP 1700 PPPPPPQQQP 1710 PLSQCSMNNS 1720 FTPAPMIMEI 1730 PESGSTGNIS 1740 IYERIPGDFG 1750 AGSYSQPSAT 1760 FSLAKLQQLT 1770 NTIMDPHAMP 1780 YSHSPAVTSY 1790 ATSVSLSNTG 1800 LAQLAPSHPL 1810 AGTPQAQATM 1820 TPPPNLASTT 1830 MNLTSPLLQC 1840 NMSATNIGIP 1850 HTQRLQGQMP 1860 VKGHISIRSK 1870 SAPLPSAAAH 1880 QQQLYGRSPS 1890 AVAMQAGPRA 1900 LAVQRGMNMG 1910 VNLMPTPAYN 1920 VNSMNMNTLN 1930 AMNSYRMTQP 1940 MMNSSYHSNP 1950 AYMNQTAQYP 1960 MQMQMGMMGS 1970 QAYTQQPMQP 1980 NPHGNMMYTG 1990 PSHHSYMNAA 2000 GVPKQSLNGP YMRR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:1903706 regulation of hemopoiesis
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Cellular Component GO:0070776 MOZ/MORF histone acetyltransferase complex
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0000786 nucleosome
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016605 PML body
Molecular Function GO:0016407 acetyltransferase activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0004402 histone acetyltransferase activity
Molecular Function GO:0010484 histone H3 acetyltransferase activity
Molecular Function GO:0036408 histone H3K14 acetyltransferase activity
Molecular Function GO:0043997 histone H4K12 acetyltransferase activity
Molecular Function GO:0046972 histone H4K16 acetyltransferase activity
Molecular Function GO:0043995 histone H4K5 acetyltransferase activity
Molecular Function GO:0043996 histone H4K8 acetyltransferase activity
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0090398 cellular senescence
Biological Process GO:0051276 chromosome organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0030099 myeloid cell differentiation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0050793 regulation of developmental process

Reference

PMID: N/A