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Overview

Uniprot IDQ92800
Protein NameHistone-lysine N-methyltransferase EZH1
Gene NameEZH1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
72 VQPVQSMKPVSGHPF

Function

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation

Protein Sequence

10 MEIPNPPTSK 20 CITYWKRKVK 30 SEYMRLRQLK 40 RLQANMGAKA 50 LYVANFAKVQ 60 EKTQILNEEW 70 KKLRVQPVQS 80 MKPVSGHPFL 90 KKCTIESIFP 100 GFASQHMLMR 110 SLNTVALVPI 120 MYSWSPLQQN 130 FMVEDETVLC 140 NIPYMGDEVK 150 EEDETFIEEL 160 INNYDGKVHG 170 EEEMIPGSVL 180 ISDAVFLELV 190 DALNQYSDEE 200 EEGHNDTSDG 210 KQDDSKEDLP 220 VTRKRKRHAI 230 EGNKKSSKKQ 240 FPNDMIFSAI 250 ASMFPENGVP 260 DDMKERYREL 270 TEMSDPNALP 280 PQCTPNIDGP 290 NAKSVQREQS 300 LHSFHTLFCR 310 RCFKYDCFLH 320 PFHATPNVYK 330 RKNKEIKIEP 340 EPCGTDCFLL 350 LEGAKEYAML 360 HNPRSKCSGR 370 RRRRHHIVSA 380 SCSNASASAV 390 AETKEGDSDR 400 DTGNDWASSS 410 SEANSRCQTP 420 TKQKASPAPP 430 QLCVVEAPSE 440 PVEWTGAEES 450 LFRVFHGTYF 460 NNFCSIARLL 470 GTKTCKQVFQ 480 FAVKESLILK 490 LPTDELMNPS 500 QKKKRKHRLW 510 AAHCRKIQLK 520 KDNSSTQVYN 530 YQPCDHPDRP 540 CDSTCPCIMT 550 QNFCEKFCQC 560 NPDCQNRFPG 570 CRCKTQCNTK 580 QCPCYLAVRE 590 CDPDLCLTCG 600 ASEHWDCKVV 610 SCKNCSIQRG 620 LKKHLLLAPS 630 DVAGWGTFIK 640 ESVQKNEFIS 650 EYCGELISQD 660 EADRRGKVYD 670 KYMSSFLFNL 680 NNDFVVDATR 690 KGNKIRFANH 700 SVNPNCYAKV 710 VMVNGDHRIG 720 IFAKRAIQAG 730 EELFFDYRYS 740 QADALKYVGI ERETDVL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0035098 ESC/E(Z) complex
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0046976 histone H3K27 methyltransferase activity
Molecular Function GO:0140951 histone H3K27 trimethyltransferase activity
Molecular Function GO:0140693 molecular condensate scaffold activity
Molecular Function GO:0031491 nucleosome binding
Molecular Function GO:0016279 protein-lysine N-methyltransferase activity
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0021766 hippocampus development
Biological Process GO:0032259 methylation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0031509 subtelomeric heterochromatin formation

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.