Search Results

Overview

Uniprot IDQ92804
Protein NameTATA-binding protein-associated factor 2N
Gene NameTAF15
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
192 RGRGGYDKDGRGPMT
261 FKQIGIIKTNKKTGK
265 GIIKTNKKTGKPMIN
354 QGRGGDPKSGDWVCP

Function

RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). Can enter the preinitiation complex together with the RNA polymerase II (Pol II)

Protein Sequence

10 MSDSGSYGQS 20 GGEQQSYSTY 30 GNPGSQGYGQ 40 ASQSYSGYGQ 50 TTDSSYGQNY 60 SGYSSYGQSQ 70 SGYSQSYGGY 80 ENQKQSSYSQ 90 QPYNNQGQQQ 100 NMESSGSQGG 110 RAPSYDQPDY 120 GQQDSYDQQS 130 GYDQHQGSYD 140 EQSNYDQQHD 150 SYSQNQQSYH 160 SQRENYSHHT 170 QDDRRDVSRY 180 GEDNRGYGGS 190 QGGGRGRGGY 200 DKDGRGPMTG 210 SSGGDRGGFK 220 NFGGHRDYGP 230 RTDADSESDN 240 SDNNTIFVQG 250 LGEGVSTDQV 260 GEFFKQIGII 270 KTNKKTGKPM 280 INLYTDKDTG 290 KPKGEATVSF 300 DDPPSAKAAI 310 DWFDGKEFHG 320 NIIKVSFATR 330 RPEFMRGGGS 340 GGGRRGRGGY 350 RGRGGFQGRG 360 GDPKSGDWVC 370 PNPSCGNMNF 380 ARRNSCNQCN 390 EPRPEDSRPS 400 GGDFRGRGYG 410 GERGYRGRGG 420 RGGDRGGYGG 430 DRSGGGYGGD 440 RSSGGGYSGD 450 RSGGGYGGDR 460 SGGGYGGDRG 470 GGYGGDRGGG 480 YGGDRGGGYG 490 GDRGGYGGDR 500 GGGYGGDRGG 510 YGGDRGGYGG 520 DRGGYGGDRG 530 GYGGDRSRGG 540 YGGDRGGGSG 550 YGGDRSGGYG 560 GDRSGGGYGG 570 DRGGGYGGDR 580 GGYGGKMGGR 590 NDYRNDQRNR PY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003730 mRNA 3'-UTR binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003712 transcription coregulator activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0048255 mRNA stabilization
Biological Process GO:0045893 positive regulation of DNA-templated transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.