Search Results

Overview

Uniprot IDQ92817
Protein NameEnvoplakin
Gene NameEVPL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1107 EEDAARRKQAEEAVA
1216 EITRLKAKLQEMAGK

Function

Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments

Protein Sequence

10 MFKGLSKGSQ 20 GKGSPKGSPA 30 KGSPKGSPSR 40 HSRAATQELA 50 LLISRMQANA 60 DQVERDILET 70 QKRLQQDRLN 80 SEQSQALQHQ 90 QETGRSLKEA 100 EVLLKDLFLD 110 VDKARRLKHP 120 QAEEIEKDIK 130 QLHERVTQEC 140 AEYRALYEKM 150 VLPPDVGPRV 160 DWARVLEQKQ 170 KQVCAGQYGP 180 GMAELEQQIA 190 EHNILQKEID 200 AYGQQLRSLV 210 GPDAATIRSQ 220 YRDLLKAASW 230 RGQSLGSLYT 240 HLQGCTRQLS 250 ALAEQQRRIL 260 QQDWSDLMAD 270 PAGVRREYEH 280 FKQHELLSQE 290 QSVNQLEDDG 300 ERMVELRHPA 310 VGPIQAHQEA 320 LKMEWQNFLN 330 LCICQETQLQ 340 HVEDYRRFQE 350 EADSVSQTLA 360 KLNSNLDAKY 370 SPAPGGPPGA 380 PTELLQQLEA 390 EEKRLAVTER 400 ATGDLQRRSR 410 DVAPLPQRRN 420 PPQQPLHVDS 430 ICDWDSGEVQ 440 LLQGERYKLV 450 DNTDPHAWVV 460 QGPGGETKRA 470 PAACFCIPAP 480 DPDAVARASR 490 LASELQALKQ 500 KLATVQSRLK 510 ASAVESLRPS 520 QQAPSGSDLA 530 NPQAQKLLTQ 540 MTRLDGDLGQ 550 IERQVLAWAR 560 APLSRPTPLE 570 DLEGRIHSHE 580 GTAQRLQSLG 590 TEKETAQKEC 600 EAFLSTRPVG 610 PAALQLPVAL 620 NSVKNKFSDV 630 QVLCSLYGEK 640 AKAALDLERQ 650 IQDADRVIRG 660 FEATLVQEAP 670 IPAEPGALQE 680 RVSELQRQRR 690 ELLEQQTCVL 700 RLHRALKASE 710 HACAALQNNF 720 QEFCQDLPRQ 730 QRQVRALTDR 740 YHAVGDQLDL 750 REKVVQDAAL 760 TYQQFKNCKD 770 NLSSWLEHLP 780 RSQVRPSDGP 790 SQIAYKLQAQ 800 KRLTQEIQSR 810 ERDRATASHL 820 SQALQAALQD 830 YELQADTYRC 840 SLEPTLAVSA 850 PKRPRVAPLQ 860 ESIQAQEKNL 870 AKAYTEVAAA 880 QQQLLQQLEF 890 ARKMLEKKEL 900 SEDIRRTHDA 910 KQGSESPAQA 920 GRESEALKAQ 930 LEEERKRVAR 940 VQHELEAQRS 950 QLLQLRTQRP 960 LERLEEKEVV 970 EFYRDPQLEG 980 SLSRVKAQVE 990 EEGKRRAGLQ 1000 ADLEVAAQKV 1010 VQLESKRKTM 1020 QPHLLTKEVT 1030 QVERDPGLDS 1040 QAAQLRIQIQ 1050 QLRGEDAVIS 1060 ARLEGLKKEL 1070 LALEKREVDV 1080 KEKVVVKEVV 1090 KVEKNLEMVK 1100 AAQALRLQME 1110 EDAARRKQAE 1120 EAVAKLQARI 1130 EDLERAISSV 1140 EPKVIVKEVK 1150 KVEQDPGLLQ 1160 ESSRLRSLLE 1170 EERTKNATLA 1180 RELSDLHSKY 1190 SVVEKQRPKV 1200 QLQERVHEIF 1210 QVDPETEQEI 1220 TRLKAKLQEM 1230 AGKRSGVEKE 1240 VEKLLPDLEV 1250 LRAQKPTVEY 1260 KEVTQEVVRH 1270 ERSPEVLREI 1280 DRLKAQLNEL 1290 VNSHGRSQEQ 1300 LIRLQGERDE 1310 WRRERAKVET 1320 KTVSKEVVRH 1330 EKDPVLEKEA 1340 ERLRQEVREA 1350 AQKRRAAEDA 1360 VYELQSKRLL 1370 LERRKPEEKV 1380 VVQEVVVTQK 1390 DPKLREEHSR 1400 LSGSLDEEVG 1410 RRRQLELEVQ 1420 QLRAGVEEQE 1430 GLLSFQEDRS 1440 KKLAVERELR 1450 QLTLRIQELE 1460 KRPPTVQEKI 1470 IMEEVVKLEK 1480 DPDLEKSTEA 1490 LRWDLDQEKT 1500 QVTELNRECK 1510 NLQVQIDVLQ 1520 KAKSQEKTIY 1530 KEVIRVQKDR 1540 VLEDERARVW 1550 EMLNRERTAR 1560 QAREEEARRL 1570 RERIDRAETL 1580 GRTWSREESE 1590 LQRARDQADQ 1600 ECGRLQQELR 1610 ALERQKQQQT 1620 LQLQEESKLL 1630 SQKTESERQK 1640 AAQRGQELSR 1650 LEAAILREKD 1660 QIYEKERTLR 1670 DLHAKVSREE 1680 LSQETQTRET 1690 NLSTKISILE 1700 PETGKDMSPY 1710 EAYKRGIIDR 1720 GQYLQLQELE 1730 CDWEEVTTSG 1740 PCGEESVLLD 1750 RKSGKQYSIE 1760 AALRCRRISK 1770 EEYHLYKDGH 1780 LPISEFALLV 1790 AGETKPSSSL 1800 SIGSIISKSP 1810 LASPAPQSTS 1820 FFSPSFSLGL 1830 GDDSFPIAGI 1840 YDTTTDNKCS 1850 IKTAVAKNML 1860 DPITGQKLLE 1870 AQAATGGIVD 1880 LLSRERYSVH 1890 KAMERGLIEN 1900 TSTQRLLNAQ 1910 KAFTGIEDPV 1920 TKKRLSVGEA 1930 VQKGWMPRES 1940 VLPHLQVQHL 1950 TGGLIDPKRT 1960 GRIPIQQALL 1970 SGMISEELAQ 1980 LLQDESSYEK 1990 DLTDPISKER 2000 LSYKEAMGRC 2010 RKDPLSGLLL 2020 LPAALEGYRC 2030 YRSASPTVPR SLR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001533 cornified envelope
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030057 desmosome
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0045111 intermediate filament cytoskeleton
Cellular Component GO:0016020 membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0008544 epidermis development
Biological Process GO:0045104 intermediate filament cytoskeleton organization
Biological Process GO:0031424 keratinization
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0018149 peptide cross-linking
Biological Process GO:0042060 wound healing

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.