Search Results
Overview
| Uniprot ID | Q92820 |
|---|---|
| Protein Name | Gamma-glutamyl hydrolase |
| Gene Name | GGH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 212 | TMNEKLKKFFNVLTT |
| 247 | GVQWHPEKAPYEWKN |
| 253 | EKAPYEWKNLDGISH |
| 281 | FFVNEARKNNHHFKS |
| 33 | PHGDTAKKPIIGILM |
Function
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate (PubMed:11005824, PubMed:8816764). May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates
Protein Sequence
10
MASPGCLLCV
20
LGLLLCGAAS
30
LELSRPHGDT
40
AKKPIIGILM
50
QKCRNKVMKN
60
YGRYYIAASY
70
VKYLESAGAR
80
VVPVRLDLTE
90
KDYEILFKSI
100
NGILFPGGSV
110
DLRRSDYAKV
120
AKIFYNLSIQ
130
SFDDGDYFPV
140
WGTCLGFEEL
150
SLLISGECLL
160
TATDTVDVAM
170
PLNFTGGQLH
180
SRMFQNFPTE
190
LLLSLAVEPL
200
TANFHKWSLS
210
VKNFTMNEKL
220
KKFFNVLTTN
230
TDGKIEFIST
240
MEGYKYPVYG
250
VQWHPEKAPY
260
EWKNLDGISH
270
APNAVKTAFY
280
LAEFFVNEAR
290
KNNHHFKSES
300
EEEKALIYQF
310
SPIYTGNISS
FQQCYIFD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035580 | specific granule lumen |
| Cellular Component | GO:1904724 | tertiary granule lumen |
| Cellular Component | GO:0005773 | vacuole |
| Molecular Function | GO:0008238 | exopeptidase activity |
| Molecular Function | GO:0034722 | gamma-glutamyl-peptidase activity |
| Molecular Function | GO:0008242 | omega peptidase activity |
| Biological Process | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.