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Overview

Uniprot IDQ92833
Protein NameProtein Jumonji
Gene NameJARID2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
38 KVLYLSLKEFKNSQK

Function

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity)

Protein Sequence

10 MSKERPKRNI 20 IQKKYDDSDG 30 IPWSEERVVR 40 KVLYLSLKEF 50 KNSQKRQHAE 60 GIAGSLKTVN 70 GLLGNDQSKG 80 LGPASEQSEN 90 EKDDASQVSS 100 TSNDVSSSDF 110 EEGPSRKRPR 120 LQAQRKFAQS 130 QPNSPSTTPV 140 KIVEPLLPPP 150 ATQISDLSKR 160 KPKTEDFLTF 170 LCLRGSPALP 180 NSMVYFGSSQ 190 DEEEVEEEDD 200 ETEDVKTATN 210 NASSSCQSTP 220 RKGKTHKHVH 230 NGHVFNGSSR 240 STREKEPVQK 250 HKSKEATPAK 260 EKHSDHRADS 270 RREQASANHP 280 AAAPSTGSSA 290 KGLAATHHHP 300 PLHRSAQDLR 310 KQVSKVNGVT 320 RMSSLGAGVT 330 SAKKMREVRP 340 SPSKTVKYTA 350 TVTKGAVTYT 360 KAKRELVKDT 370 KPNHHKPSSA 380 VNHTISGKTE 390 SSNAKTRKQV 400 LSLGGASKST 410 GPAVNGLKVS 420 GRLNPKSCTK 430 EVGGRQLREG 440 LQLREGLRNS 450 KRRLEEAHQA 460 EKPQSPPKKM 470 KGAAGPAEGP 480 GKKAPAERGL 490 LNGHVKKEVP 500 ERSLERNRPK 510 RATAGKSTPG 520 RQAHGKADSA 530 SCENRSTSQP 540 ESVHKPQDSG 550 KAEKGGGKAG 560 WAAMDEIPVL 570 RPSAKEFHDP 580 LIYIESVRAQ 590 VEKFGMCRVI 600 PPPDWRPECK 610 LNDEMRFVTQ 620 IQHIHKLGRR 630 WGPNVQRLAC 640 IKKHLKSQGI 650 TMDELPLIGG 660 CELDLACFFR 670 LINEMGGMQQ 680 VTDLKKWNKL 690 ADMLRIPRTA 700 QDRLAKLQEA 710 YCQYLLSYDS 720 LSPEEHRRLE 730 KEVLMEKEIL 740 EKRKGPLEGH 750 TENDHHKFHP 760 LPRFEPKNGL 770 IHGVAPRNGF 780 RSKLKEVGQA 790 QLKTGRRRLF 800 AQEKEVVKEE 810 EEDKGVLNDF 820 HKCIYKGRSV 830 SLTTFYRTAR 840 NIMSMCFSKE 850 PAPAEIEQEY 860 WRLVEEKDCH 870 VAVHCGKVDT 880 NTHGSGFPVG 890 KSEPFSRHGW 900 NLTVLPNNTG 910 SILRHLGAVP 920 GVTIPWLNIG 930 MVFSTSCWSR 940 DQNHLPYIDY 950 LHTGADCIWY 960 CIPAEEENKL 970 EDVVHTLLQA 980 NGTPGLQMLE 990 SNVMISPEVL 1000 CKEGIKVHRT 1010 VQQSGQFVVC 1020 FPGSFVSKVC 1030 CGYSVSETVH 1040 FATTQWTSMG 1050 FETAKEMKRR 1060 HIAKPFSMEK 1070 LLYQIAQAEA 1080 KKENGPTLST 1090 ISALLDELRD 1100 TELRQRRQLF 1110 EAGLHSSARY 1120 GSHDGSSTVA 1130 DGKKKPRKWL 1140 QLETSERRCQ 1150 ICQHLCYLSM 1160 VVQENENVVF 1170 CLECALRHVE 1180 KQKSCRGLKL 1190 MYRYDEEQII 1200 SLVNQICGKV 1210 SGKNGSIENC 1220 LSKPTPKRGP 1230 RKRATVDVPP 1240 SRLSASSSSK SASSSS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0035098 ESC/E(Z) complex
Cellular Component GO:0035097 histone methyltransferase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0046976 histone H3K27 methyltransferase activity
Molecular Function GO:0043130 ubiquitin binding
Molecular Function GO:0061649 ubiquitin-modified histone reader activity
Biological Process GO:0007417 central nervous system development
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0140718 facultative heterochromatin formation
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0048863 stem cell differentiation

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.