Overview
| Uniprot ID | Q92887 |
|---|
| Protein Name | ATP-binding cassette sub-family C member 2 |
|---|
| Gene Name | ABCC2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 698 |
VHGHITIKGTTAYVP |
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of endogenous and xenobiotic substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as hepatocytes, renal and intestinal epithelial cells, where it mediates hepatobiliary and renal excretion of conjugated substrates preventing them from being recycled back into the bloodstream (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456, PubMed:29175180, PubMed:30959153, PubMed:31704245). Involved in canalicular bile production. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin, enabling bilirubin detoxification (PubMed:10421658). Mediates the efflux of steroid glucuronates and may regulate their hepatobiliary and renal metabolic clearance. Displays low affinity but high transport velocity toward androgen conjugates such as testosterone and dihydrotestosterone glucuronates as well as toward estrogen conjugates including estradiol, estrone and estriol glucuronates (PubMed:29175180, PubMed:30959153, PubMed:31704245). May control the hepatobiliary and renal efflux of inflammatory leukotriene C4 (LTC4) and related cysteinyl leukotrienes (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). It is functionally inactive toward androgen sulfates (PubMed:39993711). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Can confer resistance to several anticancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine, by decreasing accumulation of these drugs in cells (PubMed:10220572, PubMed:11500505)
Protein Sequence
10
MLEKFCNSTF
20
WNSSFLDSPE
30
ADLPLCFEQT
40
VLVWIPLGYL
50
WLLAPWQLLH
60
VYKSRTKRSS
70
TTKLYLAKQV
80
FVGFLLILAA
90
IELALVLTED
100
SGQATVPAVR
110
YTNPSLYLGT
120
WLLVLLIQYS
130
RQWCVQKNSW
140
FLSLFWILSI
150
LCGTFQFQTL
160
IRTLLQGDNS
170
NLAYSCLFFI
180
SYGFQILILI
190
FSAFSENNES
200
SNNPSSIASF
210
LSSITYSWYD
220
SIILKGYKRP
230
LTLEDVWEVD
240
EEMKTKTLVS
250
KFETHMKREL
260
QKARRALQRR
270
QEKSSQQNSG
280
ARLPGLNKNQ
290
SQSQDALVLE
300
DVEKKKKKSG
310
TKKDVPKSWL
320
MKALFKTFYM
330
VLLKSFLLKL
340
VNDIFTFVSP
350
QLLKLLISFA
360
SDRDTYLWIG
370
YLCAILLFTA
380
ALIQSFCLQC
390
YFQLCFKLGV
400
KVRTAIMASV
410
YKKALTLSNL
420
ARKEYTVGET
430
VNLMSVDAQK
440
LMDVTNFMHM
450
LWSSVLQIVL
460
SIFFLWRELG
470
PSVLAGVGVM
480
VLVIPINAIL
490
STKSKTIQVK
500
NMKNKDKRLK
510
IMNEILSGIK
520
ILKYFAWEPS
530
FRDQVQNLRK
540
KELKNLLAFS
550
QLQCVVIFVF
560
QLTPVLVSVV
570
TFSVYVLVDS
580
NNILDAQKAF
590
TSITLFNILR
600
FPLSMLPMMI
610
SSMLQASVST
620
ERLEKYLGGD
630
DLDTSAIRHD
640
CNFDKAMQFS
650
EASFTWEHDS
660
EATVRDVNLD
670
IMAGQLVAVI
680
GPVGSGKSSL
690
ISAMLGEMEN
700
VHGHITIKGT
710
TAYVPQQSWI
720
QNGTIKDNIL
730
FGTEFNEKRY
740
QQVLEACALL
750
PDLEMLPGGD
760
LAEIGEKGIN
770
LSGGQKQRIS
780
LARATYQNLD
790
IYLLDDPLSA
800
VDAHVGKHIF
810
NKVLGPNGLL
820
KGKTRLLVTH
830
SMHFLPQVDE
840
IVVLGNGTIV
850
EKGSYSALLA
860
KKGEFAKNLK
870
TFLRHTGPEE
880
EATVHDGSEE
890
EDDDYGLISS
900
VEEIPEDAAS
910
ITMRRENSFR
920
RTLSRSSRSN
930
GRHLKSLRNS
940
LKTRNVNSLK
950
EDEELVKGQK
960
LIKKEFIETG
970
KVKFSIYLEY
980
LQAIGLFSIF
990
FIILAFVMNS
1000
VAFIGSNLWL
1010
SAWTSDSKIF
1020
NSTDYPASQR
1030
DMRVGVYGAL
1040
GLAQGIFVFI
1050
AHFWSAFGFV
1060
HASNILHKQL
1070
LNNILRAPMR
1080
FFDTTPTGRI
1090
VNRFAGDIST
1100
VDDTLPQSLR
1110
SWITCFLGII
1120
STLVMICMAT
1130
PVFTIIVIPL
1140
GIIYVSVQMF
1150
YVSTSRQLRR
1160
LDSVTRSPIY
1170
SHFSETVSGL
1180
PVIRAFEHQQ
1190
RFLKHNEVRI
1200
DTNQKCVFSW
1210
ITSNRWLAIR
1220
LELVGNLTVF
1230
FSALMMVIYR
1240
DTLSGDTVGF
1250
VLSNALNITQ
1260
TLNWLVRMTS
1270
EIETNIVAVE
1280
RITEYTKVEN
1290
EAPWVTDKRP
1300
PPDWPSKGKI
1310
QFNNYQVRYR
1320
PELDLVLRGI
1330
TCDIGSMEKI
1340
GVVGRTGAGK
1350
SSLTNCLFRI
1360
LEAAGGQIII
1370
DGVDIASIGL
1380
HDLREKLTII
1390
PQDPILFSGS
1400
LRMNLDPFNN
1410
YSDEEIWKAL
1420
ELAHLKSFVA
1430
SLQLGLSHEV
1440
TEAGGNLSIG
1450
QRQLLCLGRA
1460
LLRKSKILVL
1470
DEATAAVDLE
1480
TDNLIQTTIQ
1490
NEFAHCTVIT
1500
IAHRLHTIMD
1510
SDKVMVLDNG
1520
KIIECGSPEE
1530
LLQIPGPFYF
1540
MAKEAGIENV
NSTKF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0046581 |
intercellular canaliculus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0031982 |
vesicle |
| Molecular Function |
GO:0015431 |
ABC-type glutathione S-conjugate transporter activity |
| Molecular Function |
GO:0140359 |
ABC-type transporter activity |
| Molecular Function |
GO:0008559 |
ABC-type xenobiotic transporter activity |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0042626 |
ATPase-coupled transmembrane transporter activity |
| Molecular Function |
GO:0015127 |
bilirubin transmembrane transporter activity |
| Molecular Function |
GO:0019534 |
toxin transmembrane transporter activity |
| Molecular Function |
GO:0022857 |
transmembrane transporter activity |
| Molecular Function |
GO:0042910 |
xenobiotic transmembrane transporter activity |
| Biological Process |
GO:0015721 |
bile acid and bile salt transport |
| Biological Process |
GO:0015723 |
bilirubin transport |
| Biological Process |
GO:0042167 |
heme catabolic process |
| Biological Process |
GO:0071716 |
leukotriene transport |
| Biological Process |
GO:0010629 |
negative regulation of gene expression |
| Biological Process |
GO:0070633 |
transepithelial transport |
| Biological Process |
GO:0055085 |
transmembrane transport |
| Biological Process |
GO:0150104 |
transport across blood-brain barrier |
| Biological Process |
GO:0046618 |
xenobiotic export from cell |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
| Biological Process |
GO:0006855 |
xenobiotic transmembrane transport |
| Biological Process |
GO:1990962 |
xenobiotic transport across blood-brain barrier |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.