Search Results
Overview
| Uniprot ID | Q92889 |
|---|---|
| Protein Name | DNA repair endonuclease XPF |
| Gene Name | ERCC4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 491 | TLKKKKRKLTLTQMV |
Function
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair
Protein Sequence
10
MESGQPARRI
20
AMAPLLEYER
30
QLVLELLDTD
40
GLVVCARGLG
50
ADRLLYHFLQ
60
LHCHPACLVL
70
VLNTQPAEEE
80
YFINQLKIEG
90
VEHLPRRVTN
100
EITSNSRYEV
110
YTQGGVIFAT
120
SRILVVDFLT
130
DRIPSDLITG
140
ILVYRAHRII
150
ESCQEAFILR
160
LFRQKNKRGF
170
IKAFTDNAVA
180
FDTGFCHVER
190
VMRNLFVRKL
200
YLWPRFHVAV
210
NSFLEQHKPE
220
VVEIHVSMTP
230
TMLAIQTAIL
240
DILNACLKEL
250
KCHNPSLEVE
260
DLSLENAIGK
270
PFDKTIRHYL
280
DPLWHQLGAK
290
TKSLVQDLKI
300
LRTLLQYLSQ
310
YDCVTFLNLL
320
ESLRATEKAF
330
GQNSGWLFLD
340
SSTSMFINAR
350
ARVYHLPDAK
360
MSKKEKISEK
370
MEIKEGEETK
380
KELVLESNPK
390
WEALTEVLKE
400
IEAENKESEA
410
LGGPGQVLIC
420
ASDDRTCSQL
430
RDYITLGAEA
440
FLLRLYRKTF
450
EKDSKAEEVW
460
MKFRKEDSSK
470
RIRKSHKRPK
480
DPQNKERAST
490
KERTLKKKKR
500
KLTLTQMVGK
510
PEELEEEGDV
520
EEGYRREISS
530
SPESCPEEIK
540
HEEFDVNLSS
550
DAAFGILKEP
560
LTIIHPLLGC
570
SDPYALTRVL
580
HEVEPRYVVL
590
YDAELTFVRQ
600
LEIYRASRPG
610
KPLRVYFLIY
620
GGSTEEQRYL
630
TALRKEKEAF
640
EKLIREKASM
650
VVPEEREGRD
660
ETNLDLVRGT
670
ASADVSTDTR
680
KAGGQEQNGT
690
QQSIVVDMRE
700
FRSELPSLIH
710
RRGIDIEPVT
720
LEVGDYILTP
730
EMCVERKSIS
740
DLIGSLNNGR
750
LYSQCISMSR
760
YYKRPVLLIE
770
FDPSKPFSLT
780
SRGALFQEIS
790
SNDISSKLTL
800
LTLHFPRLRI
810
LWCPSPHATA
820
ELFEELKQSK
830
PQPDAATALA
840
ITADSETLPE
850
SEKYNPGPQD
860
FLLKMPGVNA
870
KNCRSLMHHV
880
KNIAELAALS
890
QDELTSILGN
900
AANAKQLYDF
910
IHTSFAEVVS
KGKGKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0070522 | ERCC4-ERCC1 complex |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000109 | nucleotide-excision repair complex |
| Cellular Component | GO:0000110 | nucleotide-excision repair factor 1 complex |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003684 | damaged DNA binding |
| Molecular Function | GO:0004520 | DNA endonuclease activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Molecular Function | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity |
| Molecular Function | GO:0001094 | TFIID-class transcription factor complex binding |
| Biological Process | GO:0034644 | cellular response to UV |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0000724 | double-strand break repair via homologous recombination |
| Biological Process | GO:0006303 | double-strand break repair via nonhomologous end joining |
| Biological Process | GO:1905765 | negative regulation of protection from non-homologous end joining at telomere |
| Biological Process | GO:0032205 | negative regulation of telomere maintenance |
| Biological Process | GO:1904357 | negative regulation of telomere maintenance via telomere lengthening |
| Biological Process | GO:0006289 | nucleotide-excision repair |
| Biological Process | GO:1901255 | nucleotide-excision repair involved in interstrand cross-link repair |
| Biological Process | GO:0000712 | resolution of meiotic recombination intermediates |
| Biological Process | GO:0009411 | response to UV |
| Biological Process | GO:0000723 | telomere maintenance |
| Biological Process | GO:0061819 | telomeric DNA-containing double minutes formation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.