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Overview

Uniprot IDQ92901
Protein NameRibosomal protein uL3-like
Gene NameRPL3L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
373 KFIDTTSKFGHGRFQ

Function

Heart- and skeletal muscle-specific component of the ribosome, which regulates muscle function. Component of the large ribosomal subunit in striated muscle cells: replaces the RPL3 paralog in the ribosome in these cells. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Inhibits myotube growth and muscle function

Protein Sequence

10 MSHRKFSAPR 20 HGHLGFLPHK 30 RSHRHRGKVK 40 TWPRDDPSQP 50 VHLTAFLGYK 60 AGMTHTLREV 70 HRPGLKISKR 80 EEVEAVTIVE 90 TPPLVVVGVV 100 GYVATPRGLR 110 SFKTIFAEHL 120 SDECRRRFYK 130 DWHKSKKKAF 140 TKACKRWRDT 150 DGKKQLQKDF 160 AAMKKYCKVI 170 RVIVHTQMKL 180 LPFRQKKAHI 190 MEIQLNGGTV 200 AEKVAWAQAR 210 LEKQVPVHSV 220 FSQSEVIDVI 230 AVTKGRGVKG 240 VTSRWHTKKL 250 PRKTHKGLRK 260 VACIGAWHPA 270 RVGCSIARAG 280 QKGYHHRTEL 290 NKKIFRIGRG 300 PHMEDGKLVK 310 NNASTSYDVT 320 AKSITPLGGF 330 PHYGEVNNDF 340 VMLKGCIAGT 350 KKRVITLRKS 360 LLVHHSRQAV 370 ENIELKFIDT 380 TSKFGHGRFQ 390 TAQEKRAFMG 400 PQKKHLEKET PETSGDL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0022625 cytosolic large ribosomal subunit
Cellular Component GO:0016020 membrane
Cellular Component GO:0005840 ribosome
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003735 structural constituent of ribosome
Biological Process GO:0002181 cytoplasmic translation
Biological Process GO:1901740 negative regulation of myoblast fusion
Biological Process GO:0010832 negative regulation of myotube differentiation
Biological Process GO:0016202 regulation of striated muscle tissue development
Biological Process GO:0006941 striated muscle contraction
Biological Process GO:0006412 translation

Reference

PMID: N/A