Search Results

Overview

Uniprot ID	Q92917
Protein Name	G-patch domain and KOW motifs-containing protein
Gene Name	GPKOW
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
114	ELIAESKKSLEEREN
135	LAIPMIQKGCTPSGE
192	RTFNQVVKPRVNSLR
201	RVNSLRPKGLGLGAN
346	RQDGPAAKSEKAAPR
46	AGPSPEEKDFLKTVE

Function

RNA-binding protein involved in pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

Protein Sequence

10 MADSKEGVLP 20 LTAASTAPIS 30 FGFTRTSARR 40 RLADSGDGAG 50 PSPEEKDFLK 60 TVEGRELQSV 70 KPQEAPKELV 80 IPLIQNGHRR 90 QPPARPPGPS 100 TDTGALADGV 110 VSQAVKELIA 120 ESKKSLEERE 130 NAGVDPTLAI 140 PMIQKGCTPS 150 GEGADSEPRA 160 ETVPEEANYE 170 AVPVEAYGLA 180 MLRGMGWKPG 190 EGIGRTFNQV 200 VKPRVNSLRP 210 KGLGLGANLT 220 EAQALTPTGP 230 SRMPRPDEEQ 240 EKDKEDQPQG 250 LVPGGAVVVL 260 SGPHRGLYGK 270 VEGLDPDNVR 280 AMVRLAVGSR 290 VVTVSEYYLR 300 PVSQQEFDKN 310 TLDLRQQNGT 320 ASSRKTLWNQ 330 ELYIQQDNSE 340 RKRKHLPDRQ 350 DGPAAKSEKA 360 APRSQHWLHR 370 DLRVRFVDNM 380 YKGGQYYNTK 390 MIIEDVLSPD 400 TCVCRTDEGR 410 VLEGLREDML 420 ETLVPKAEGD 430 RVMVVLGPQT 440 GRVGHLLSRD 450 RARSRALVQL 460 PRENQVVELH 470 YDAICQYMGP SDTDDD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005681	spliceosomal complex
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0000398	mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.