Search Results
Overview
| Uniprot ID | Q92925 |
|---|---|
| Protein Name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 |
| Gene Name | SMARCD2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 514 | VGRHIFAKVQQRRQE |
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (PubMed:28369036)
Protein Sequence
10
MSGRGAGGFP
20
LPPLSPGGGA
30
VAAALGAPPP
40
PAGPGMLPGP
50
ALRGPGPAGG
60
VGGPGAAAFR
70
PMGPAGPAAQ
80
YQRPGMSPGN
90
RMPMAGLQVG
100
PPAGSPFGAA
110
APLRPGMPPT
120
MMDPFRKRLL
130
VPQAQPPMPA
140
QRRGLKRRKM
150
ADKVLPQRIR
160
ELVPESQAYM
170
DLLAFERKLD
180
QTIARKRMEI
190
QEAIKKPLTQ
200
KRKLRIYISN
210
TFSPSKAEGD
220
SAGTAGTPGG
230
TPAGDKVASW
240
ELRVEGKLLD
250
DPSKQKRKFS
260
SFFKSLVIEL
270
DKELYGPDNH
280
LVEWHRMPTT
290
QETDGFQVKR
300
PGDLNVKCTL
310
LLMLDHQPPQ
320
YKLDPRLARL
330
LGVHTQTRAA
340
IMQALWLYIK
350
HNQLQDGHER
360
EYINCNRYFR
370
QIFSCGRLRF
380
SEIPMKLAGL
390
LQHPDPIVIN
400
HVISVDPNDQ
410
KKTACYDIDV
420
EVDDPLKAQM
430
SNFLASTTNQ
440
QEIASLDVKI
450
HETIESINQL
460
KTQRDFMLSF
470
STDPQDFIQE
480
WLRSQRRDLK
490
IITDVIGNPE
500
EERRAAFYHQ
510
PWAQEAVGRH
520
IFAKVQQRRQ
530
ELEQVLGIRL
T
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0016514 | SWI/SNF complex |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0006337 | nucleosome disassembly |
| Biological Process | GO:0045597 | positive regulation of cell differentiation |
| Biological Process | GO:2000781 | positive regulation of double-strand break repair |
| Biological Process | GO:0045663 | positive regulation of myoblast differentiation |
| Biological Process | GO:0045582 | positive regulation of T cell differentiation |
| Biological Process | GO:0070316 | regulation of G0 to G1 transition |
| Biological Process | GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0030071 | regulation of mitotic metaphase/anaphase transition |
| Biological Process | GO:2000819 | regulation of nucleotide-excision repair |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
PMID: N/A