Overview
| Uniprot ID | Q92930 |
|---|
| Protein Name | Ras-related protein Rab-8B |
|---|
| Gene Name | RAB8B |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 3 |
*****MAKTYDYLFK |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (Probable). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433)
Protein Sequence
10
MAKTYDYLFK
20
LLLIGDSGVG
30
KTCLLFRFSE
40
DAFNTTFIST
50
IGIDFKIRTI
60
ELDGKKIKLQ
70
IWDTAGQERF
80
RTITTAYYRG
90
AMGIMLVYDI
100
TNEKSFDNIK
110
NWIRNIEEHA
120
SSDVERMILG
130
NKCDMNDKRQ
140
VSKERGEKLA
150
IDYGIKFLET
160
SAKSSANVEE
170
AFFTLARDIM
180
TKLNRKMNDS
190
NSAGAGGPVK
200
ITENRSKKTS
FFRCSLL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0051286 |
cell tip |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0010008 |
endosome membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0005778 |
peroxisomal membrane |
| Cellular Component |
GO:0045335 |
phagocytic vesicle |
| Cellular Component |
GO:0030670 |
phagocytic vesicle membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Cellular Component |
GO:0030140 |
trans-Golgi network transport vesicle |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0005102 |
signaling receptor binding |
| Molecular Function |
GO:0030911 |
TPR domain binding |
| Biological Process |
GO:0019882 |
antigen processing and presentation |
| Biological Process |
GO:0150115 |
cell-substrate junction organization |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:0006887 |
exocytosis |
| Biological Process |
GO:0031346 |
positive regulation of cell projection organization |
| Biological Process |
GO:0051461 |
positive regulation of corticotropin secretion |
| Biological Process |
GO:0045046 |
protein import into peroxisome membrane |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.