Search Results
Overview
| Uniprot ID | Q92934 |
|---|---|
| Protein Name | Bcl2-associated agonist of cell death |
| Gene Name | BAD |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 36 | DGPSGSGKHHRQAPG |
Function
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways
Protein Sequence
10
MFQIPEFEPS
20
EQEDSSSAER
30
GLGPSPAGDG
40
PSGSGKHHRQ
50
APGLLWDASH
60
QQEQPTSSSH
70
HGGAGAVEIR
80
SRHSSYPAGT
90
EDDEGMGEEP
100
SPFRGRSRSA
110
PPNLWAAQRY
120
GRELRRMSDE
130
FVDSFKKGLP
140
RPKSAGTATQ
150
MRQSSSWTRV
160
FQSWWDRNLG
RGSSAPSQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097138 | BAD-BCL-2 complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0140608 | cysteine-type endopeptidase activator activity |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Biological Process | GO:0046031 | ADP metabolic process |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0046034 | ATP metabolic process |
| Biological Process | GO:0071456 | cellular response to hypoxia |
| Biological Process | GO:0071396 | cellular response to lipid |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0071316 | cellular response to nicotine |
| Biological Process | GO:0097191 | extrinsic apoptotic signaling pathway |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0097193 | intrinsic apoptotic signaling pathway |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0046931 | pore complex assembly |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0010508 | positive regulation of autophagy |
| Biological Process | GO:0050679 | positive regulation of epithelial cell proliferation |
| Biological Process | GO:0032024 | positive regulation of insulin secretion |
| Biological Process | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| Biological Process | GO:1902220 | positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
| Biological Process | GO:0010918 | positive regulation of mitochondrial membrane potential |
| Biological Process | GO:0045862 | positive regulation of proteolysis |
| Biological Process | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| Biological Process | GO:2000078 | positive regulation of type B pancreatic cell development |
| Biological Process | GO:0046902 | regulation of mitochondrial membrane permeability |
| Biological Process | GO:0044342 | type B pancreatic cell proliferation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.