Search Results
Overview
| Uniprot ID | Q92947 |
|---|---|
| Protein Name | Glutaryl-CoA dehydrogenase, mitochondrial |
| Gene Name | GCDH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 202 | AHYNSSNKSYTLNGT |
| 334 | ARNQLIQKKLADMLT |
| 371 | PEMVSLLKRNNCGKA |
| 377 | LKRNNCGKALDIARQ |
| 42 | RTQSQLAKSSRPEFD |
Function
Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive
Protein Sequence
10
MALRGVSVRL
20
LSRGPGLHVL
30
RTWVSSAAQT
40
EKGGRTQSQL
50
AKSSRPEFDW
60
QDPLVLEEQL
70
TTDEILIRDT
80
FRTYCQERLM
90
PRILLANRNE
100
VFHREIISEM
110
GELGVLGPTI
120
KGYGCAGVSS
130
VAYGLLAREL
140
ERVDSGYRSA
150
MSVQSSLVMH
160
PIYAYGSEEQ
170
RQKYLPQLAK
180
GELLGCFGLT
190
EPNSGSDPSS
200
METRAHYNSS
210
NKSYTLNGTK
220
TWITNSPMAD
230
LFVVWARCED
240
GCIRGFLLEK
250
GMRGLSAPRI
260
QGKFSLRASA
270
TGMIIMDGVE
280
VPEENVLPGA
290
SSLGGPFGCL
300
NNARYGIAWG
310
VLGASEFCLH
320
TARQYALDRM
330
QFGVPLARNQ
340
LIQKKLADML
350
TEITLGLHAC
360
LQLGRLKDQD
370
KAAPEMVSLL
380
KRNNCGKALD
390
IARQARDMLG
400
GNGISDEYHV
410
IRHAMNLEAV
420
NTYEGTHDIH
430
ALILGRAITG
IQAFTASK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0000062 | fatty-acyl-CoA binding |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0004361 | glutaryl-CoA dehydrogenase activity |
| Biological Process | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| Biological Process | GO:0046949 | fatty-acyl-CoA biosynthetic process |
| Biological Process | GO:0033514 | L-lysine catabolic process to acetyl-CoA via L-pipecolate |
| Biological Process | GO:0033512 | L-lysine catabolic process to acetyl-CoA via L-saccharopine |
| Biological Process | GO:0006568 | L-tryptophan metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.