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Overview

Uniprot IDQ92954
Protein NameProteoglycan 4
Gene NamePRG4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1230 IKDAGYPKPIFKGFG
1330 ARLAYQDKGVLHNEV

Function

Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface

Protein Sequence

10 MAWKTLPIYL 20 LLLLSVFVIQ 30 QVSSQDLSSC 40 AGRCGEGYSR 50 DATCNCDYNC 60 QHYMECCPDF 70 KRVCTAELSC 80 KGRCFESFER 90 GRECDCDAQC 100 KKYDKCCPDY 110 ESFCAEVHNP 120 TSPPSSKKAP 130 PPSGASQTIK 140 STTKRSPKPP 150 NKKKTKKVIE 160 SEEITEEHSV 170 SENQESSSSS 180 SSSSSSSTIR 190 KIKSSKNSAA 200 NRELQKKLKV 210 KDNKKNRTKK 220 KPTPKPPVVD 230 EAGSGLDNGD 240 FKVTTPDTST 250 TQHNKVSTSP 260 KITTAKPINP 270 RPSLPPNSDT 280 SKETSLTVNK 290 ETTVETKETT 300 TTNKQTSTDG 310 KEKTTSAKET 320 QSIEKTSAKD 330 LAPTSKVLAK 340 PTPKAETTTK 350 GPALTTPKEP 360 TPTTPKEPAS 370 TTPKEPTPTT 380 IKSAPTTPKE 390 PAPTTTKSAP 400 TTPKEPAPTT 410 TKEPAPTTPK 420 EPAPTTTKEP 430 APTTTKSAPT 440 TPKEPAPTTP 450 KKPAPTTPKE 460 PAPTTPKEPT 470 PTTPKEPAPT 480 TKEPAPTTPK 490 EPAPTAPKKP 500 APTTPKEPAP 510 TTPKEPAPTT 520 TKEPSPTTPK 530 EPAPTTTKSA 540 PTTTKEPAPT 550 TTKSAPTTPK 560 EPSPTTTKEP 570 APTTPKEPAP 580 TTPKKPAPTT 590 PKEPAPTTPK 600 EPAPTTTKKP 610 APTTPKEPAP 620 TTPKETAPTT 630 PKKLTPTTPE 640 KLAPTTPEKP 650 APTTPEELAP 660 TTPEEPTPTT 670 PEEPAPTTPK 680 AAAPNTPKEP 690 APTTPKEPAP 700 TTPKEPAPTT 710 PKETAPTTPK 720 GTAPTTLKEP 730 APTTPKKPAP 740 KELAPTTTKE 750 PTSTTSDKPA 760 PTTPKGTAPT 770 TPKEPAPTTP 780 KEPAPTTPKG 790 TAPTTLKEPA 800 PTTPKKPAPK 810 ELAPTTTKGP 820 TSTTSDKPAP 830 TTPKETAPTT 840 PKEPAPTTPK 850 KPAPTTPETP 860 PPTTSEVSTP 870 TTTKEPTTIH 880 KSPDESTPEL 890 SAEPTPKALE 900 NSPKEPGVPT 910 TKTPAATKPE 920 MTTTAKDKTT 930 ERDLRTTPET 940 TTAAPKMTKE 950 TATTTEKTTE 960 SKITATTTQV 970 TSTTTQDTTP 980 FKITTLKTTT 990 LAPKVTTTKK 1000 TITTTEIMNK 1010 PEETAKPKDR 1020 ATNSKATTPK 1030 PQKPTKAPKK 1040 PTSTKKPKTM 1050 PRVRKPKTTP 1060 TPRKMTSTMP 1070 ELNPTSRIAE 1080 AMLQTTTRPN 1090 QTPNSKLVEV 1100 NPKSEDAGGA 1110 EGETPHMLLR 1120 PHVFMPEVTP 1130 DMDYLPRVPN 1140 QGIIINPMLS 1150 DETNICNGKP 1160 VDGLTTLRNG 1170 TLVAFRGHYF 1180 WMLSPFSPPS 1190 PARRITEVWG 1200 IPSPIDTVFT 1210 RCNCEGKTFF 1220 FKDSQYWRFT 1230 NDIKDAGYPK 1240 PIFKGFGGLT 1250 GQIVAALSTA 1260 KYKNWPESVY 1270 FFKRGGSIQQ 1280 YIYKQEPVQK 1290 CPGRRPALNY 1300 PVYGETTQVR 1310 RRRFERAIGP 1320 SQTHTIRIQY 1330 SPARLAYQDK 1340 GVLHNEVKVS 1350 ILWRGLPNVV 1360 TSAISLPNIR 1370 KPDGYDYYAF 1380 SKDQYYNIDV 1390 PSRTARAITT 1400 RSGQTLSKVW YNCP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005615 extracellular space
Molecular Function GO:0030247 polysaccharide binding
Molecular Function GO:0005044 scavenger receptor activity
Biological Process GO:0006955 immune response

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.