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Overview

Uniprot IDQ92973
Protein NameTransportin-1
Gene NameTNPO1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
687 MYQCMQDKMPEVRQS
889 DQFPLPLKERLAAFY

Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). In vitro, mediates nuclear import of SRP19 (PubMed:11682607). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571). Main mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with the karyopherins KPNA1 and KPNA2 (PubMed:35446349)

Protein Sequence

10 MVWDRQTKME 20 YEWKPDEQGL 30 QQILQLLKES 40 QSPDTTIQRT 50 VQQKLEQLNQ 60 YPDFNNYLIF 70 VLTKLKSEDE 80 PTRSLSGLIL 90 KNNVKAHFQN 100 FPNGVTDFIK 110 SECLNNIGDS 120 SPLIRATVGI 130 LITTIASKGE 140 LQNWPDLLPK 150 LCSLLDSEDY 160 NTCEGAFGAL 170 QKICEDSAEI 180 LDSDVLDRPL 190 NIMIPKFLQF 200 FKHSSPKIRS 210 HAVACVNQFI 220 ISRTQALMLH 230 IDSFIENLFA 240 LAGDEEPEVR 250 KNVCRALVML 260 LEVRMDRLLP 270 HMHNIVEYML 280 QRTQDQDENV 290 ALEACEFWLT 300 LAEQPICKDV 310 LVRHLPKLIP 320 VLVNGMKYSD 330 IDIILLKGDV 340 EEDETIPDSE 350 QDIRPRFHRS 360 RTVAQQHDED 370 GIEEEDDDDD 380 EIDDDDTISD 390 WNLRKCSAAA 400 LDVLANVYRD 410 ELLPHILPLL 420 KELLFHHEWV 430 VKESGILVLG 440 AIAEGCMQGM 450 IPYLPELIPH 460 LIQCLSDKKA 470 LVRSITCWTL 480 SRYAHWVVSQ 490 PPDTYLKPLM 500 TELLKRILDS 510 NKRVQEAACS 520 AFATLEEEAC 530 TELVPYLAYI 540 LDTLVFAFSK 550 YQHKNLLILY 560 DAIGTLADSV 570 GHHLNKPEYI 580 QMLMPPLIQK 590 WNMLKDEDKD 600 LFPLLECLSS 610 VATALQSGFL 620 PYCEPVYQRC 630 VNLVQKTLAQ 640 AMLNNAQPDQ 650 YEAPDKDFMI 660 VALDLLSGLA 670 EGLGGNIEQL 680 VARSNILTLM 690 YQCMQDKMPE 700 VRQSSFALLG 710 DLTKACFQHV 720 KPCIADFMPI 730 LGTNLNPEFI 740 SVCNNATWAI 750 GEISIQMGIE 760 MQPYIPMVLH 770 QLVEIINRPN 780 TPKTLLENTA 790 ITIGRLGYVC 800 PQEVAPMLQQ 810 FIRPWCTSLR 820 NIRDNEEKDS 830 AFRGICTMIS 840 VNPSGVIQDF 850 IFFCDAVASW 860 INPKDDLRDM 870 FCKILHGFKN 880 QVGDENWRRF 890 SDQFPLPLKE RLAAFYGV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005929 cilium
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0061608 nuclear import signal receptor activity
Molecular Function GO:0008139 nuclear localization sequence binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0006606 protein import into nucleus

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.