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Overview

Uniprot ID	Q92994
Protein Name	Transcription factor IIIB 90 kDa subunit
Gene Name	BRF1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
304	GQRKLRMKQLEQVLS
590	DPVTSVGKRLRPLVS
602	LVSTQPAKKVATGEA
79	GFHVNLGKESRAQTL

Function

General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter

Protein Sequence

10 MTGRVCRGCG 20 GTDIELDAAR 30 GDAVCTACGS 40 VLEDNIIVSE 50 VQFVESSGGG 60 SSAVGQFVSL 70 DGAGKTPTLG 80 GGFHVNLGKE 90 SRAQTLQNGR 100 RHIHHLGNQL 110 QLNQHCLDTA 120 FNFFKMAVSR 130 HLTRGRKMAH 140 VIAACLYLVC 150 RTEGTPHMLL 160 DLSDLLQVNV 170 YVLGKTFLLL 180 ARELCINAPA 190 IDPCLYIPRF 200 AHLLEFGEKN 210 HEVSMTALRL 220 LQRMKRDWMH 230 TGRRPSGLCG 240 AALLVAARMH 250 DFRRTVKEVI 260 SVVKVCESTL 270 RKRLTEFEDT 280 PTSQLTIDEF 290 MKIDLEEECD 300 PPSYTAGQRK 310 LRMKQLEQVL 320 SKKLEEVEGE 330 ISSYQDAIEI 340 ELENSRPKAK 350 GGLASLAKDG 360 STEDTASSLC 370 GEEDTEDEEL 380 EAAASHLNKD 390 LYRELLGGAP 400 GSSEAAGSPE 410 WGGRPPALGS 420 LLDPLPTAAS 430 LGISDSIREC 440 ISSQSSDPKD 450 ASGDGELDLS 460 GIDDLEIDRY 470 ILNESEARVK 480 AELWMRENAE 490 YLREQREKEA 500 RIAKEKELGI 510 YKEHKPKKSC 520 KRREPIQAST 530 AREAIEKMLE 540 QKKISSKINY 550 SVLRGLSSAG 560 GGSPHREDAQ 570 PEHSASARKL 580 SRRRTPASRS 590 GADPVTSVGK 600 RLRPLVSTQP 610 AKKVATGEAL 620 LPSSPTLGAE 630 PARPQAVLVE 640 SGPVSYHADE 650 EADEEEPDEE 660 DGEPCVSALQ 670 MMGSNDYGCD GDEDDGY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0000126	transcription factor TFIIIB complex
Cellular Component	GO:0097550	transcription preinitiation complex
Molecular Function	GO:0000995	RNA polymerase III general transcription initiation factor activity
Molecular Function	GO:0001006	RNA polymerase III type 3 promoter sequence-specific DNA binding
Molecular Function	GO:0017025	TBP-class protein binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006352	DNA-templated transcription initiation
Biological Process	GO:0009303	rRNA transcription
Biological Process	GO:0006383	transcription by RNA polymerase III
Biological Process	GO:0006384	transcription initiation at RNA polymerase III promoter
Biological Process	GO:0070897	transcription preinitiation complex assembly
Biological Process	GO:0009304	tRNA transcription

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.