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Overview

Uniprot IDQ93033
Protein NameImmunoglobulin superfamily member 2
Gene NameCD101
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
354 QGELQVSKLGPKAFS

Function

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells

Protein Sequence

10 MAGISYVASF 20 FLLLTKLSIG 30 QREVTVQKGP 40 LFRAEGYPVS 50 IGCNVTGHQG 60 PSEQHFQWSV 70 YLPTNPTQEV 80 QIISTKDAAF 90 SYAVYTQRVR 100 SGDVYVERVQ 110 GNSVLLHISK 120 LQMKDAGEYE 130 CHTPNTDEKY 140 YGSYSAKTNL 150 IVIPDTLSAT 160 MSSQTLGKEE 170 GEPLALTCEA 180 SKATAQHTHL 190 SVTWYLTQDG 200 GGSQATEIIS 210 LSKDFILVPG 220 PLYTERFAAS 230 DVQLNKLGPT 240 TFRLSIERLQ 250 SSDQGQLFCE 260 ATEWIQDPDE 270 TWMFITKKQT 280 DQTTLRIQPA 290 VKDFQVNITA 300 DSLFAEGKPL 310 ELVCLVVSSG 320 RDPQLQGIWF 330 FNGTEIAHID 340 AGGVLGLKND 350 YKERASQGEL 360 QVSKLGPKAF 370 SLKIFSLGPE 380 DEGAYRCVVA 390 EVMKTRTGSW 400 QVLQRKQSPD 410 SHVHLRKPAA 420 RSVVMSTKNK 430 QQVVWEGETL 440 AFLCKAGGAE 450 SPLSVSWWHI 460 PRDQTQPEFV 470 AGMGQDGIVQ 480 LGASYGVPSY 490 HGNTRLEKMD 500 WATFQLEITF 510 TAITDSGTYE 520 CRVSEKSRNQ 530 ARDLSWTQKI 540 SVTVKSLESS 550 LQVSLMSRQP 560 QVMLTNTFDL 570 SCVVRAGYSD 580 LKVPLTVTWQ 590 FQPASSHIFH 600 QLIRITHNGT 610 IEWGNFLSRF 620 QKKTKVSQSL 630 FRSQLLVHDA 640 TEEETGVYQC 650 EVEVYDRNSL 660 YNNRPPRASA 670 ISHPLRIAVT 680 LPESKLKVNS 690 RSQVQELSIN 700 SNTDIECSIL 710 SRSNGNLQLA 720 IIWYFSPVST 730 NASWLKILEM 740 DQTNVIKTGD 750 EFHTPQRKQK 760 FHTEKVSQDL 770 FQLHILNVED 780 SDRGKYHCAV 790 EEWLLSTNGT 800 WHKLGEKKSG 810 LTELKLKPTG 820 SKVRVSKVYW 830 TENVTEHREV 840 AIRCSLESVG 850 SSATLYSVMW 860 YWNRENSGSK 870 LLVHLQHDGL 880 LEYGEEGLRR 890 HLHCYRSSST 900 DFVLKLHQVE 910 MEDAGMYWCR 920 VAEWQLHGHP 930 SKWINQASDE 940 SQRMVLTVLP 950 SEPTLPSRIC 960 SSAPLLYFLF 970 ICPFVLLLLL 980 LISLLCLYWK 990 ARKLSTLRSN 1000 TRKEKALWVD 1010 LKEAGGVTTN 1020 RREDEEEDEG N

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Biological Process GO:0007166 cell surface receptor signaling pathway

Reference

[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.