Search Results
Overview
| Uniprot ID | Q93045 |
|---|---|
| Protein Name | Stathmin-2 |
| Gene Name | STMN2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 129 | EENNNFSKMAEEKLI |
| 76 | RTLASPKKKDLSLEE |
| 77 | TLASPKKKDLSLEEI |
| 86 | LSLEEIQKKLEAAEE |
Function
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity)
Protein Sequence
10
MAKTAMAYKE
20
KMKELSMLSL
30
ICSCFYPEPR
40
NINIYTYDDM
50
EVKQINKRAS
60
GQAFELILKP
70
PSPISEAPRT
80
LASPKKKDLS
90
LEEIQKKLEA
100
AEERRKSQEA
110
QVLKQLAEKR
120
EHEREVLQKA
130
LEENNNFSKM
140
AEEKLILKME
150
QIKENREANL
160
AAIIERLQEK
170
ERHAAEVRRN
KELQVELSG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0015631 | tubulin binding |
| Biological Process | GO:1990090 | cellular response to nerve growth factor stimulus |
| Biological Process | GO:0007019 | microtubule depolymerization |
| Biological Process | GO:0007026 | negative regulation of microtubule depolymerization |
| Biological Process | GO:0031115 | negative regulation of microtubule polymerization |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0031117 | positive regulation of microtubule depolymerization |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0031110 | regulation of microtubule polymerization or depolymerization |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.