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Overview

Uniprot IDQ93050
Protein NameV-type proton ATPase 116 kDa subunit a 1
Gene NameATP6V0A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
119 NTNQEALKRNFLELT
70 RKLRFVEKEIRKANI

Function

Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes. V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles (PubMed:33065002, PubMed:33833240, PubMed:34909687). In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (PubMed:33833240)

Protein Sequence

10 MGELFRSEEM 20 TLAQLFLQSE 30 AAYCCVSELG 40 ELGKVQFRDL 50 NPDVNVFQRK 60 FVNEVRRCEE 70 MDRKLRFVEK 80 EIRKANIPIM 90 DTGENPEVPF 100 PRDMIDLEAN 110 FEKIENELKE 120 INTNQEALKR 130 NFLELTELKF 140 ILRKTQQFFD 150 EMADPDLLEE 160 SSSLLEPSEM 170 GRGTPLRLGF 180 VAGVINRERI 190 PTFERMLWRV 200 CRGNVFLRQA 210 EIENPLEDPV 220 TGDYVHKSVF 230 IIFFQGDQLK 240 NRVKKICEGF 250 RASLYPCPET 260 PQERKEMASG 270 VNTRIDDLQM 280 VLNQTEDHRQ 290 RVLQAAAKNI 300 RVWFIKVRKM 310 KAIYHTLNLC 320 NIDVTQKCLI 330 AEVWCPVTDL 340 DSIQFALRRG 350 TEHSGSTVPS 360 ILNRMQTNQT 370 PPTYNKTNKF 380 TYGFQNIVDA 390 YGIGTYREIN 400 PAPYTIITFP 410 FLFAVMFGDF 420 GHGILMTLFA 430 VWMVLRESRI 440 LSQKNENEMF 450 STVFSGRYII 460 LLMGVFSMYT 470 GLIYNDCFSK 480 SLNIFGSSWS 490 VRPMFTYNWT 500 EETLRGNPVL 510 QLNPALPGVF 520 GGPYPFGIDP 530 IWNIATNKLT 540 FLNSFKMKMS 550 VILGIIHMLF 560 GVSLSLFNHI 570 YFKKPLNIYF 580 GFIPEIIFMT 590 SLFGYLVILI 600 FYKWTAYDAH 610 TSENAPSLLI 620 HFINMFLFSY 630 PESGYSMLYS 640 GQKGIQCFLV 650 VVALLCVPWM 660 LLFKPLVLRR 670 QYLRRKHLGT 680 LNFGGIRVGN 690 GPTEEDAEII 700 QHDQLSTHSE 710 DADEPSEDEV 720 FDFGDTMVHQ 730 AIHTIEYCLG 740 CISNTASYLR 750 LWALSLAHAQ 760 LSEVLWTMVI 770 HIGLSVKSLA 780 GGLVLFFFFT 790 AFATLTVAIL 800 LIMEGLSAFL 810 HALRLHWVEF 820 QNKFYSGTGF 830 KFLPFSFEHI REGKFEE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030665 clathrin-coated vesicle membrane
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0101003 ficolin-1-rich granule membrane
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0030670 phagocytic vesicle membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030667 secretory granule membrane
Cellular Component GO:0030672 synaptic vesicle membrane
Cellular Component GO:0016471 vacuolar proton-transporting V-type ATPase complex
Cellular Component GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
Molecular Function GO:0051117 ATPase binding
Molecular Function GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process GO:0048388 endosomal lumen acidification
Biological Process GO:0007042 lysosomal lumen acidification
Biological Process GO:1902600 proton transmembrane transport
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:0097401 synaptic vesicle lumen acidification
Biological Process GO:0007035 vacuolar acidification

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.