Search Results

Overview

Uniprot IDQ93052
Protein NameLipoma-preferred partner
Gene NameLPP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 VQGNPGGKTLEERRS
176 QPPLTATKKSTLKPQ
177 PPLTATKKSTLKPQP
327 QGHPNTWKREPGYTP
353 YPVTGPKKTYITDPV
44 STQQPPKKFAPVVAP
54 PVVAPKPKYNPYKQP

Function

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus

Protein Sequence

10 MSHPSWLPPK 20 STGEPLGHVP 30 ARMETTHSFG 40 NPSISVSTQQ 50 PPKKFAPVVA 60 PKPKYNPYKQ 70 PGGEGDFLPP 80 PPPPLDDSSA 90 LPSISGNFPP 100 PPPLDEEAFK 110 VQGNPGGKTL 120 EERRSSLDAE 130 IDSLTSILAD 140 LECSSPYKPR 150 PPQSSTGSTA 160 SPPVSTPVTG 170 HKRMVIPNQP 180 PLTATKKSTL 190 KPQPAPQAGP 200 IPVAPIGTLK 210 PQPQPVPASY 220 TTASTSSRPT 230 FNVQVKSAQP 240 SPHYMAAPSS 250 GQIYGSGPQG 260 YNTQPVPVSG 270 QCPPPSTRGG 280 MDYAYIPPPG 290 LQPEPGYGYA 300 PNQGRYYEGY 310 YAAGPGYGGR 320 NDSDPTYGQQ 330 GHPNTWKREP 340 GYTPPGAGNQ 350 NPPGMYPVTG 360 PKKTYITDPV 370 SAPCAPPLQP 380 KGGHSGQLGP 390 SSVAPSFRPE 400 DELEHLTKKM 410 LYDMENPPAD 420 EYFGRCARCG 430 ENVVGEGTGC 440 TAMDQVFHVD 450 CFTCIICNNK 460 LRGQPFYAVE 470 KKAYCEPCYI 480 NTLEQCNVCS 490 KPIMERILRA 500 TGKAYHPHCF 510 TCVMCHRSLD 520 GIPFTVDAGG 530 LIHCIEDFHK 540 KFAPRCSVCK 550 EPIMPAPGQE 560 ETVRIVALDR 570 DFHVHCYRCE 580 DCGGLLSEGD 590 NQGCYPLDGH 600 ILCKTCNSAR 610 IRVLTAKAST DL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030054 cell junction
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0098609 cell-cell adhesion

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[7] Hu J, Jin Z, Gao Y, Liu Q, Yu Y et al.. Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients.. J Proteome Res 24(4):1732-1744. 2025 Apr 4. PMID: 40112136.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.