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Overview

Uniprot ID	Q93075
Protein Name	3'-5' RNA nuclease TATDN2
Gene Name	TATDN2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
197	AIQGILGKSMPKRKG

Function

Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA structure (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292)

Protein Sequence

10 MASERGKVKH 20 NWSSTSEGCP 30 RKRSCLREPC 40 DVAPSSRPAQ 50 RSASRSGGPS 60 SPKRLKAQKE 70 DDVACSRRLS 80 WGSSRRRNNS 90 SSSFSPHFLG 100 PGVGGAASKG 110 CLIRNTRGFL 120 SSGGSPLRPA 130 NASLEEMASL 140 EEEACSLKVD 150 SKDSSHNSTN 160 SEFAAEAEGQ 170 NDTIEEPNKV 180 QKRKRDRLRD 190 QGSTMIYLKA 200 IQGILGKSMP 210 KRKGEAATRA 220 KPSAAEHPSH 230 GEGPARSEGP 240 AKTAEGAARS 250 VTVTAAQKEK 260 DATPEVSMEE 270 DKTVPERSSF 280 YDRRVVIDPQ 290 EKPSEEPLGD 300 RRTVIDKCSP 310 PLEFLDDSDS 320 HLEIQKHKDR 330 EVVMEHPSSG 340 SDWSDVEEIS 350 TVRFSQEEPV 360 SLKPSAVPEP 370 SSFTTDYVMY 380 PPHLYSSPWC 390 DYASYWTSSP 400 KPSSYPSTGS 410 SSNDAAQVGK 420 SSRSRMSDYS 430 PNSTGSVQNT 440 SRDMEASEEG 450 WSQNSRSFRF 460 SRSSEEREVK 470 EKRTFQEEMP 480 PRPCGGHASS 490 SLPKSHLEPS 500 LEEGFIDTHC 510 HLDMLYSKLS 520 FQGTFTKFRK 530 IYSSSFPKEF 540 QGCISDFCDP 550 RTLTDCLWEE 560 LLKEDLVWGA 570 FGCHPHFARY 580 YSESQERNLL 590 QALRHPKAVA 600 FGEMGLDYSY 610 KCTTPVPEQH 620 KVFERQLQLA 630 VSLKKPLVIH 640 CREADEDLLE 650 IMKKFVPPDY 660 KIHRHCFTGS 670 YPVIEPLLKY 680 FPNMSVGFTA 690 VLTYSSAWEA 700 REALRQIPLE 710 RIIVETDAPY 720 FLPRQVPKSL 730 CQYAHPGLAL 740 HTVREIARVK 750 DQPLSLTLAA 760 LRENTSRLYS L

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0004527	exonuclease activity
Molecular Function	GO:0046872	metal ion binding

Reference

PMID: N/A