Search Results
Overview
| Uniprot ID | Q93084 |
|---|---|
| Protein Name | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
| Gene Name | ATP2A3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 204 | PRAVNQDKKNMLFSG |
| 999 | MHEEMSQK******* |
Function
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction
Protein Sequence
10
MEAAHLLPAA
20
DVLRHFSVTA
30
EGGLSPAQVT
40
GARERYGPNE
50
LPSEEGKSLW
60
ELVLEQFEDL
70
LVRILLLAAL
80
VSFVLAWFEE
90
GEETTTAFVE
100
PLVIMLILVA
110
NAIVGVWQER
120
NAESAIEALK
130
EYEPEMGKVI
140
RSDRKGVQRI
150
RARDIVPGDI
160
VEVAVGDKVP
170
ADLRLIEIKS
180
TTLRVDQSIL
190
TGESVSVTKH
200
TEAIPDPRAV
210
NQDKKNMLFS
220
GTNITSGKAV
230
GVAVATGLHT
240
ELGKIRSQMA
250
AVEPERTPLQ
260
RKLDEFGRQL
270
SHAISVICVA
280
VWVINIGHFA
290
DPAHGGSWLR
300
GAVYYFKIAV
310
ALAVAAIPEG
320
LPAVITTCLA
330
LGTRRMARKN
340
AIVRSLPSVE
350
TLGCTSVICS
360
DKTGTLTTNQ
370
MSVCRMFVVA
380
EADAGSCLLH
390
EFTISGTTYT
400
PEGEVRQGDQ
410
PVRCGQFDGL
420
VELATICALC
430
NDSALDYNEA
440
KGVYEKVGEA
450
TETALTCLVE
460
KMNVFDTDLQ
470
ALSRVERAGA
480
CNTVIKQLMR
490
KEFTLEFSRD
500
RKSMSVYCTP
510
TRPHPTGQGS
520
KMFVKGAPES
530
VIERCSSVRV
540
GSRTAPLTPT
550
SREQILAKIR
560
DWGSGSDTLR
570
CLALATRDAP
580
PRKEDMELDD
590
CSKFVQYETD
600
LTFVGCVGML
610
DPPRPEVAAC
620
ITRCYQAGIR
630
VVMITGDNKG
640
TAVAICRRLG
650
IFGDTEDVAG
660
KAYTGREFDD
670
LSPEQQRQAC
680
RTARCFARVE
690
PAHKSRIVEN
700
LQSFNEITAM
710
TGDGVNDAPA
720
LKKAEIGIAM
730
GSGTAVAKSA
740
AEMVLSDDNF
750
ASIVAAVEEG
760
RAIYSNMKQF
770
IRYLISSNVG
780
EVVCIFLTAI
790
LGLPEALIPV
800
QLLWVNLVTD
810
GLPATALGFN
820
PPDLDIMEKL
830
PRSPREALIS
840
GWLFFRYLAI
850
GVYVGLATVA
860
AATWWFVYDA
870
EGPHINFYQL
880
RNFLKCSEDN
890
PLFAGIDCEV
900
FESRFPTTMA
910
LSVLVTIEMC
920
NALNSVSENQ
930
SLLRMPPWMN
940
PWLLVAVAMS
950
MALHFLILLV
960
PPLPLIFQVT
970
PLSGRQWVVV
980
LQISLPVILL
990
DEALKYLSRN
HMHEEMSQK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0015085 | calcium ion transmembrane transporter activity |
| Molecular Function | GO:0030899 | calcium-dependent ATPase activity |
| Molecular Function | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005388 | P-type calcium transporter activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:1903515 | calcium ion transport from cytosol to endoplasmic reticulum |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| Biological Process | GO:0034220 | monoatomic ion transmembrane transport |
| Biological Process | GO:1903779 | regulation of cardiac conduction |
| Biological Process | GO:0150104 | transport across blood-brain barrier |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0031090 | organelle membrane |
| Cellular Component | GO:0031095 | platelet dense tubular network membrane |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.