Search Results
Overview
| Uniprot ID | Q93088 |
|---|---|
| Protein Name | Betaine--homocysteine S-methyltransferase 1 |
| Gene Name | BHMT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 138 | CKSETEVKKVFLQQL |
| 139 | KSETEVKKVFLQQLE |
| 150 | QQLEVFMKKNVDFLI |
| 207 | ECAVRLVKAGASIIG |
| 226 | FDPTISLKTVKLMKE |
| 232 | LKTVKLMKEGLEAAR |
| 241 | GLEAARLKAHLMSQP |
| 283 | ATRWDIQKYAREAYN |
| 340 | SGLDMHTKPWVRARA |
| 349 | WVRARARKEYWENLR |
| 369 | PYNPSMSKPDGWGVT |
| 377 | PDGWGVTKGTAELMQ |
| 386 | TAELMQQKEATTEQQ |
| 395 | ATTEQQLKELFEKQK |
| 40 | LEKRGYVKAGPWTPE |
| 400 | QLKELFEKQKFKSQ* |
| 7 | *MPPVGGKKAKKGIL |
| 93 | RGNYVLEKISGQEVN |
Function
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline
Protein Sequence
10
MPPVGGKKAK
20
KGILERLNAG
30
EIVIGDGGFV
40
FALEKRGYVK
50
AGPWTPEAAV
60
EHPEAVRQLH
70
REFLRAGSNV
80
MQTFTFYASE
90
DKLENRGNYV
100
LEKISGQEVN
110
EAACDIARQV
120
ADEGDALVAG
130
GVSQTPSYLS
140
CKSETEVKKV
150
FLQQLEVFMK
160
KNVDFLIAEY
170
FEHVEEAVWA
180
VETLIASGKP
190
VAATMCIGPE
200
GDLHGVPPGE
210
CAVRLVKAGA
220
SIIGVNCHFD
230
PTISLKTVKL
240
MKEGLEAARL
250
KAHLMSQPLA
260
YHTPDCNKQG
270
FIDLPEFPFG
280
LEPRVATRWD
290
IQKYAREAYN
300
LGVRYIGGCC
310
GFEPYHIRAI
320
AEELAPERGF
330
LPPASEKHGS
340
WGSGLDMHTK
350
PWVRARARKE
360
YWENLRIASG
370
RPYNPSMSKP
380
DGWGVTKGTA
390
ELMQQKEATT
400
EQQLKELFEK
QKFKSQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0047150 | betaine-homocysteine S-methyltransferase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071266 | 'de novo' L-methionine biosynthetic process |
| Biological Process | GO:0006579 | amino-acid betaine catabolic process |
| Biological Process | GO:0006577 | amino-acid betaine metabolic process |
| Biological Process | GO:0071267 | L-methionine salvage |
| Biological Process | GO:0032259 | methylation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.